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Acetaminophen Hepatotoxicity: The First 35 Years
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“The reason for this widespread toxicity is that, unlike drugs associated with idiosyncrasy, APAP is a dose‐related hepatotoxin, with all mammalian species susceptible to liver injury in doses only 2 to 3 times therapeutic dosing.161”
From AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury (2023) · cites this paper as [161]
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Cites
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Stravitz, R. T., & Lee, W. M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31894-x · Cited by 844
Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
(2016) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2015.00052 · Cited by 744
Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct
Fontana, R. J., Watkins, P. B., Bonkovsky, H. L., Chalasani, N., Davern, T., Serrano, J., & Rochon, J. (2009) · Drug Safety · doi:10.2165/00002018-200932010-00005 · Cited by 486
Acetaminophen Hepatotoxicity and Acute Liver Failure
Chun, L. J., Tong, M. J., Busuttil, R. W., & Hiatt, J. R. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31818a3854 · Cited by 348
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Fontana, R. J., Liou, I., Reuben, A., Suzuki, A., Fiel, M. I., Lee, W., & Navarro, V. (2023) · Hepatology · doi:10.1002/hep.32689 · Cited by 340
Acetaminophen-related Hepatotoxicity
Bunchorntavakul, C., & Reddy, K. R. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.07.005 · Cited by 322
A Review of Acetaminophen Poisoning
Hodgman, M. J., & Garrard, A. R. (2012) · Critical Care Clinics · doi:10.1016/j.ccc.2012.07.006 · Cited by 314
Acute Liver Failure Including Acetaminophen Overdose
Fontana, R. J. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.03.005 · Cited by 249
James, L. P., Letzig, L., Simpson, P. M., Capparelli, E., Roberts, D. W., Hinson, J. A., Davern, T. J., & Lee, W. M. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.026195 · Cited by 175
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand
Chiew, A. L., Reith, D., Pomerleau, A., Wong, A., Isoardi, K. Z., Soderstrom, J., & Buckley, N. A. (2020) · Medical Journal of Australia · doi:10.5694/mja2.50428 · Cited by 145
Drug-induced liver injury: Is it somehow foreseeable?
Tarantino, G., Minno, M. N. D. D., & Capone, D. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.2817 · Cited by 137
Chiew, A. L., Isbister, G. K., Kirby, K. A., Page, C. B., Chan, B. S. H., & Buckley, N. A. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1334915 · Cited by 107
Nguyen, G. C., Sam, J., & Thuluvath, P. J. (2008) · Hepatology · doi:10.1002/hep.22536 · Cited by 107
Stine, J. G., & Lewis, J. H. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2016.1127756 · Cited by 104
Risk prediction of hepatotoxicity in paracetamol poisoning
Wong, A., & Graudins, A. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1317349 · Cited by 88
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series
Link, S. L., Rampon, G., Osmon, S., Scalzo, A. J., & Rumack, B. H. (2022) · Clinical Toxicology · doi:10.1080/15563650.2021.1996591 · Cited by 38
Self-citationBateman, D. N., Dart, R. C., Dear, J. W., Prescott, L. F., & Rumack, B. H. (2023) · Clinical Toxicology · doi:10.1080/15563650.2023.2293452 · Cited by 25
Self-citationHoegberg, L. C. G., Gosselin, S., Buckley, N. A., Wood, D. M., Shepherd, G., Hanley, J., Bates, N., St-Onge, M., Caravati, E. M., Smith, S. W., et al. (2026) · Clinical Toxicology · doi:10.1080/15563650.2025.2609807 · Cited by 7
Metadata
- Authors
- Rumack, B. H.
- Venue
- Journal of Toxicology: Clinical Toxicology
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 40
- Issue
- 1
- Pages
- 3-20
- ISSN
- 0731-3810
- Cited by
- 266
- References
- 9
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.