The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism*†
Abstract
At present, the methods and enzymology of the UDP-glucuronosyltransferases (UGTs) lag behind that of the cytochromes P450 (CYPs). About 15 human UGTs have been identified, and knowledge about their regulation, substrate selectivity, and tissue distribution has progressed recently. Alamethicin has been characterized as a treatment to remove the latency of microsomal glucuronidations. Most UGT isoforms appear to have a distinct hepatic and/or extrahepatic expression, resulting in significant expression in kidney, intestine, and steroid target tissues. The gastrointestinal tract possesses a complex expression pattern largely containing members of the UGT1A subfamily. Thus, these forms are poised to participate in the first pass metabolism of oral drugs. The authors and others have identified a significant expression of UGT1A1 in human small intestine, an enzyme possessing considerable allelic variability and a polymorphic expression pattern in intestine. Intestinal glucuronidation therefore plays a major role not only in first pass metabolism, but also in the degree of interindividual variation in overall oral bioavailability. Due to issues such as significant genetic variability and tissue localization in first-pass organs, clearance due to UGT1A1 should be minimized for new drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Goodman and Gilman's The Pharmacological Basis of Therapeutics
Hastings, R. C. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540120077042 · Cited by 2,371
Clinical pharmacokinetics; concepts and applications
(1989) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(89)90348-0 · Cited by 2,223
Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease
Tukey, R. H., & Strassburg, C. P. (2000) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.581 · Cited by 1,523
Opioid analgesics and antagonists
Reisine, T. (1996) · Medical Entomology and Zoology · Cited by 1,205
Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Gigleux, S. F., Green, M., Hum, D. W., Iyanagi, T., et al. (1997) · Pharmacogenetics · doi:10.1097/00008571-199708000-00001 · Cited by 1,183
The Hill equation revisited: uses and misuses
Weiss, J. N. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.11.9285481 · Cited by 1,000
Beutler, E., Gelbart, T., & Demina, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8170 · Cited by 853
Paine, M. F., Khalighi, M., Fisher, J. M., Shen, D. D., Kunze, K. L., Marsh, C. L., Perkins, J. D., & Thummel, K. E. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37149-6 · Cited by 789
Self-citationRole of Pharmacokinetics and Metabolism in Drug Discovery and Development
Lin, J. H., & Lu, A. Y. H. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01340-1 · Cited by 708
Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin
Bechinger, B. (1997) · Journal of Membrane Biology · doi:10.1007/s002329900201 · Cited by 602
Cited by
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
Brandon, E. F. A., Raap, C. D., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00128-5 · Cited by 567
Spencer, J. P. E., Abd El Mohsen, M. M., & Rice-Evans, C. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.11.010 · Cited by 317
Zhang, D., Chando, T. J., Everett, D. W., Patten, C. J., Dehal, S. S., & Humphreys, W. G. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.005447 · Cited by 286
Komura, H., & Iwaki, M. (2011) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.597401 · Cited by 78
Kemper, R. A., & Nabb, D. L. (2005) · Drug and Chemical Toxicology · doi:10.1081/dct-200064468 · Cited by 44
Mangiferin glucuronidation: important hepatic modulation of antioxidant activity
van der Merwe, J. D., Joubert, E., Manley, M., de Beer, D., Malherbe, C. J., & Gelderblom, W. C. A. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.11.018 · Cited by 31
Treatment of hypopituitarism in patients receiving antiepileptic drugs
Paragliola, R. M., Prete, A., Kaplan, P. W., Corsello, S. M., & Salvatori, R. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70081-6 · Cited by 22
Li, T., Zheng, Y., Fu, F., Ji, H., Chen, X., Zhao, Y., Zhao, D., Li, N., & Zhang, L. (2011) · Xenobiotica · doi:10.3109/00498254.2011.573018 · Cited by 9
Metadata
- Authors
- Fisher, M. B., Paine, M. F., Strelevitz, T. J., & Wrighton, S. A.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 33
- Issue
- 3-4
- Pages
- 273-297
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2110482855
- Cited by
- 375
- References
- 55
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
