Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells

Ehrhart‐Bornstein, Monika; Arakelyan, Karen; Krug, Alexander W.; Scherbaum, Werner A.; Bornstein, Stefan R.

doi:10.1081/erc-200044122

Cited by 80Hormonal Regulation and HypertensionAdipokines, Inflammation, and Metabolic DiseasesRenin-Angiotensin System Studies

Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells

Ehrhart‐Bornstein, Monika, Arakelyan, Karen, Krug, Alexander W., Scherbaum, Werner A., Bornstein, Stefan R.·2004·Endocrine Research

DOI 10.1081/erc-200044122

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Abstract

Obesity has become an epidemic problem in Western societies contributing to several disease processes including metabolic diseases, hypertension, and cardiovascular disease. Overweight and obesity are frequently associated with increased plasma levels of aldosterone suggesting a direct link between obesity hypertension and increased mineralocorticoid levels. The adipocyte has long been suggested to be directly involved in the regulation of the body's homeostasis and recent evidence now proves that human fat is a highly active endocrine tissue. We therefore tested the hypothesis that adipocyte secretory products directly stimulate adrenocortical aldosterone secretion. Indeed, secretory products from isolated human adipocytes strongly stimulated steroidogenesis in human adrenocortical cells (NCI-H295R), as well as in bovine adrenocortical cells with a predominant effect on mineralocorticoid secretion. In conclusion, a possible direct link exists between fat tissue metabolism and adrenal mineralocorticoid secretion that may be responsible for obesity-related hypertension.

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“MRs on adipocytes promoted the expression of inflammatory adipokines (-), giving rise to lower insulin receptor expression and impaired insulin-induced glucose uptake ().”
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“The adipocyte MRs may mediate a proadipogenic effect of both aldosterone () and GCs ().”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [173]

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Adipocytes, aldosterone and obesity-related hypertension
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Obesity as A Risk Factor for Hypertension
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Authors: Ehrhart‐Bornstein, M., Arakelyan, K., Krug, A. W., Scherbaum, W. A., & Bornstein, S. R.
Affiliations: Deutsches Diabetes-Zentrum e.V. (DE)
Technische Universität Dresden (DE)
ORCID: Krug, Alexander W.
Bornstein, Stefan R.
Venue: Endocrine Research
Publisher: Informa UK Limited
Published: 2004-01
Volume: 30
Issue: 4
Pages: 865-870
ISSN: 0743-5800 (ISSN-L)
1532-4206
DOI: 10.1081/erc-200044122
OpenAlex: W2037933025
Cited by: 80
References: 16
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 12
FWCI: 1.44
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Research (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Funders: Deutscher Akademischer Austauschdienst
Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords: obesity, hypertension, aldosterone secretion, adipocytes, adipokines, adipose tissue endocrine function, steroidogenesis, mineralocorticoids, adrenocortical cells, H295R cells
MeSH terms: Adrenal Cortex, Adult, Aldosterone, Animals, Cattle, Cells, Cultured, Female, Humans, Hypertension, Mineralocorticoids, Obesity, Steroids, Adipocytes

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Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells

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