Fat tissue metabolism and adrenal steroid secretion
Abstract
Obesity has reached epidemic proportions in Western societies, contributing to metabolic diseases, hypertension, and vascular diseases. White adipose tissue has traditionally been regarded merely as lipid, and consequently, as energy storage. However, recent data revealed the importance of adipose tissue as a highly active endocrine organ and its involvement in the body's metabolism and homeostasis. Obesity is associated with several endocrine disorders, including adrenocortical malfunction. Because of the central role of adrenal function in the body's homeostasis, adrenal malfunction is important in the development of other obesity-related abnormalities. Therefore, in this short review, we summarize recent data on obesity-induced changes in adrenocortical mineralocorticoid, glucocorticoid, and androgen secretions and their consequences for metabolism.
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Mineralocorticoid receptors on adipocytes promote inflammatory adipokine expression, leading to lower insulin receptor expression and impaired insulin-induced glucose uptake.
“MRs on adipocytes promoted the expression of inflammatory adipokines (-), giving rise to lower insulin receptor expression and impaired insulin-induced glucose uptake ().”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [177]
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- Authors
- Lamounier-Zepter, V., & Ehrhart-Bornstein, M.
- Venue
- Current Hypertension Reports
- Published
- 2006-01
- Volume
- 8
- Issue
- 1
- Pages
- 30-34
- ISSN
- 1522-6417 (ISSN-L)
- 1534-3111
- OpenAlex
- W2005692880
- Cited by
- 34
- References
- 56
- Citations by year
- 2026: 1 · 2023: 3 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2012: 5
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Hypertension Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- obesity, white adipose tissue, adipokines, adrenal steroid secretion, adrenocortical dysfunction, mineralocorticoids, glucocorticoids, androgens, metabolic homeostasis, hypertension
- MeSH terms
- Adipose Tissue, Adrenal Cortex Hormones, Humans, Obesity, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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