The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.
Open accessAbstract
Retinal ganglion neurons extend axons that grow along astroglial cell surfaces in the developing optic pathway. To identify the molecules that may mediate axon extension in vivo, antibodies to neuronal cell surface proteins were tested for their effects on neurite outgrowth by embryonic chick retinal neurons cultured on astrocyte monolayers. Neurite outgrowth by retinal neurons from embryonic day 7 (E7) and E11 chick embryos depended on the function of a calcium-dependent cell adhesion molecule (N-cadherin) and beta 1-class integrin extracellular matrix receptors. The inhibitory effects of either antibody on process extension could not be accounted for by a reduction in the attachment of neurons to astrocytes. The role of a third cell adhesion molecule, NCAM, changed during development. Anti-NCAM had no detectable inhibitory effects on neurite outgrowth by E7 retinal neurons. In contrast, E11 retinal neurite outgrowth was strongly dependent on NCAM function. Thus, N-cadherin, integrins, and NCAM are likely to regulate axon extension in the optic pathway, and their relative importance varies with developmental age.
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Cites
Laminin–a glycoprotein from basement membranes
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 2,378
Raff, M., Abney, E., Cohen, J., Lindsay, R., & Noble, M. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-06-01289.1983 · Cited by 759
Cited by
Expression of tenascin in the developing and adult cerebellar cortex
Bartsch, S., Bartsch, U., Dorries, U., Faissner, A., Weller, A., Ekblom, P., & Schachner, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00736.1992 · Cited by 271
Sheppard, A., Hamilton, S., & Pearlman, A. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-12-03928.1991 · Cited by 249
Schäfer, M., Bräuer, A. U., Savaskan, N. E., Rathjen, F. G., & Brümmendorf, T. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.010 · Cited by 86
László, Z. I., & Lele, Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.972059 · Cited by 49
Lu (1999) · doi:10.1002/(sici)1097-4636(199908)46:2
Metadata
- Authors
- Neugebauer, K. M., Tomaselli, K. J., Lilien, J., & Reichardt, L. F.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1988-09-01
- Volume
- 107
- Issue
- 3
- Pages
- 1177-1187
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1973524445
- Cited by
- 322
- References
- 2
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Neugebauer, K. M., Tomaselli, K. J., Lilien, J., & Reichardt, L. F. (1988). N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro. The Journal of cell biology. https://doi.org/10.1083/jcb.107.3.1177
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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