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Cited by 49Neurogenesis and neuroplasticity mechanismsCell Adhesion Molecules ResearchGenetics and Neurodevelopmental Disorders

Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases.

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László, Zsófia I., Lele, Zsolt·2022·Frontiers in Neuroscience
DOI 10.3389/fnins.2022.972059PMC PMC9539934
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Abstract

CDH2 belongs to the classic cadherin family of Ca 2+ -dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including maintenance of neuroepithelial integrity, neural tube closure (neurulation), confinement of radial glia progenitor cells (RGPCs) to the ventricular zone and maintaining their proliferation-differentiation balance, postmitotic neural precursor migration, axon guidance, synaptic development and maintenance. In the past few years, direct and indirect evidence linked CDH2 to various neurological diseases, and in this review, we summarize recent developments regarding CDH2 function and its involvement in pathological alterations of the CNS.

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  • Cadherin signaling has been linked to synaptic adhesion stability and neurodegeneration.

    “Cadherin signaling has also been linked to synaptic adhesion stability and neurodegeneration (Ando et al., 2011; Arikkath and Reichardt, 2008; Laszlo and Lele, 2022; Mysore et al., 2008), and APOE isoforms differentially modulate components of cadherin–catenin complexes (Ahmad et al., 2020; Zhang et al., 2024).”

    From Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch (2026) · cites this paper as Laszlo and Lele, 2022

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Sorted by citations

Authors
László, Z. I., & Lele, Z.
Affiliations
  • University of Dundee (GB)
  • HUN-REN Institute of Experimental Medicine (HU)
Corresponding author
Lele, Zsolt
ORCID
Venue
Frontiers in Neuroscience
Publisher
Frontiers Media SA
Published
2022-09-23
Volume
16
Pages
972059-972059
ISSN
1662-453X (ISSN-L)
DOI
10.3389/fnins.2022.972059
PMC
PMC9539934
OpenAlex
W4296995576
Cited by
49
References
8
Citations by year
2026: 15 · 2025: 15 · 2024: 13 · 2023: 6
FWCI
1.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Motor Neurone Disease Association (Laszlo/Oct21/977-799)
  • Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (2017-1.2.1-NKP-2017-00002)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
N-cadherin, adhesion molecules, β-catenin signaling, brain development, neurodegenerative diseases, neural tube closure, axon guidance, synaptic development

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