Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion
Abstract
The IgLON subgroup of the immunoglobulin superfamily consists of four members that are thought to be important in neural cell-cell recognition. Here, we cloned and characterized the murine IgLON subgroup member neurotractin/kilon, in the context of brain development and axonal regeneration. Neurotractin/kilon was found to be upregulated during brain development and is expressed on neurites of primary hippocampal neurons. To elucidate a potential role for neurotractin/kilon during regeneration in the CNS, we performed lesions in the entorhinal cortex, and showed that the expression of neurotractin/kilon is induced on reactive astrocytes. Notably, the expression on reactive astrocytes appears specifically in the denervated outer molecular layer of the dentate gyrus, where regenerative axon sprouting occurs. In vitro assays demonstrated that neurotractin/kilon attracts hippocampal axons in the stripe assay and that astroglial neurotractin/kilon promotes neurite outgrowth. These results suggest a function for neurotractin/kilon as a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation.
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There is a prominent genetic overlap between ASD and ADHD (rG=0.360, p=1.24 x 10^-12).
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Self-citationIgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons
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- Authors
- Schäfer, M., Bräuer, A. U., Savaskan, N. E., Rathjen, F. G., & Brümmendorf, T.
- Affiliations
- Max Delbrück Center (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Schäfer, Michael
- Rathjen, Fritz G.
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 29
- Issue
- 4
- Pages
- 580-590
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2005724066
- Cited by
- 86
- References
- 2
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- immunoglobulin superfamily, neurite outgrowth, reactive astrocytes, axon regeneration, entorhinal cortex lesion, hippocampal neurons, axon attraction, dentate gyrus molecular layer, axonal sprouting, brain development
- MeSH terms
- Animals, Astrocytes, Brain Injuries, Chlorocebus aethiops, Chick Embryo, Denervation, Disease Models, Animal, Gliosis, Growth Substances, Membrane Proteins, Mice, Inbred C57BL, Molecular Sequence Data, Nerve Regeneration, Nerve Tissue Proteins, Neuronal Plasticity, Sequence Homology, Nucleic Acid, Cell Adhesion Molecules, Neuronal, Sequence Homology, Amino Acid, DNA, Complementary, Entorhinal Cortex, Dentate Gyrus, COS Cells, Avian Proteins, Mice, Rats
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