The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice.
Abstract
The distribution of human low density lipoprotein (LDL) receptors was studied by immunofluorescence and immunoelectron microscopy in epithelial cells of transgenic mice that express high levels of receptors under control of the metallothionein-I promoter. In hepatocytes and intestinal epithelial cells, the receptors were confined to the basal and basolateral surfaces, respectively. Very few LDL receptors were present in coated pits or intracellular vesicles. In striking contrast, in the epithelium of the renal tubule the receptors were present on the apical (lumenal) surface where they appeared to be concentrated at the base of microvilli and were abundant in vesicles of the endocytic recycling pathway. Intravenously administered LDL colloidal gold conjugates bound to the receptors on hepatocyte microvilli and were slowly internalized, apparently through slow migration into coated pits. We conclude that (a) sorting of LDL receptors to the surface of different epithelial cells varies with each tissue; and (b) in addition to a signal for clustering in coated pits, the LDL receptor may contain a signal for retention in noncoated membrane that is manifest in hepatocytes and intestinal epithelial cells, but not in renal epithelial cells or cultured human fibroblasts.
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The distribution of LDLR outside coated pits in WIF-B cells is similar to the distribution of LDLR in the livers of mice expressing a human LDLR transgene.
“which is similar to the distribution of LDLR in the livers of mice expressing a human LDLR transgene (22).”
From The Modular Adaptor Protein Autosomal Recessive Hypercholesterolemia (ARH) Promotes Low Density Lipoprotein Receptor Clustering into Clathrin-coated Pits (2005) · cites this paper as [22]
It is unlikely that an inappropriate anchorage of LDLR in coated pits is the major cause of LDLR malfunction in arh-/- hepatocytes.
“Therefore, it is unlikely that an inappropriate anchorage of LDLR in coated pits is the major cause of LDLR malfunction in arhϪ/Ϫ hepatocytes.”
LDLRs are dispersed on the plasma membrane of hepatocytes but clustered in coated pits on fibroblasts.
“It must be noted, however, that LDLRs are dispersed on the plasma membrane of hepatocytes but clustered in coated pits on fibroblasts (17).”
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Citations
Cites
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
Brown, M. S., & Goldstein, J. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111044 · Cited by 545
Self-citationHofmann, S. L., Russell, D. W., Brown, M. S., Goldstein, J. L., & Hammer, R. E. (1988) · Science · doi:10.1126/science.3344433 · Cited by 117
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ARH Is a Modular Adaptor Protein That Interacts with the LDL Receptor, Clathrin, and AP-2
He, G., Gupta, S., Yi, M., Michaely, P., Hobbs, H. H., & Cohen, J. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208539200 · Cited by 232
The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH
Maurer, M. E., & Cooper, J. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03217 · Cited by 195
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors
Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., & Goldstein, J. L. (1990) · Science · doi:10.1126/science.2244210 · Cited by 175
Self-citationGaruti, R., Jones, C., Li, W.-P., Michaely, P., Herz, J., Gerard, R. D., Cohen, J. C., & Hobbs, H. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509394200 · Cited by 91
Michaely, P., Li, W.-P., Anderson, R. G. W., Cohen, J. C., & Hobbs, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405242200 · Cited by 66
Self-citationSirinian, M. I., Belleudi, F., Campagna, F., Ceridono, M., Garofalo, T., Quagliarini, F., Verna, R., Calandra, S., Bertolini, S., Sorice, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504343200 · Cited by 42
Metadata
- Authors
- Pathak, R. K., Yokode, M., Hammer, R. E., Hofmann, S. L., Brown, M. S., Goldstein, J. L., & Anderson, R. G.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1990-08-01
- Volume
- 111
- Issue
- 2
- Pages
- 347-359
- ISSN
- 0021-9525
- 1540-8140
- PMC
- PMC2116187
- Cited by
- 72
- References
- 2
- Language
- en
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