The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure.
Open accessAbstract
We have used light microscopy and serial thin-section electron microscopy to visualize intermediates of chromosome decondensation during G1 progression in synchronized CHO cells. In early G1, tightly coiled 100-130-nm "chromonema" fibers are visualized within partially decondensed chromatin masses. Progression from early to middle G1 is accompanied by a progressive uncoiling and straightening of these chromonema fibers. Further decondensation in later G1 and early S phase results in predominantly 60-80-nm chromonema fibers that can be traced up to 2-3 microns in length as discrete fibers. Abrupt transitions in diameter from 100-130 to 60-80 nm along individual fibers are suggestive of coiling of the 60-80-nm chromonema fibers to form the thicker 100-130-nm chromonema fiber. Local unfolding of these chromonema fibers, corresponding to DNA regions tens to hundreds of kilobases in length, reveal more loosely folded and extended 30-nm chromatin fibers. Kinks and supercoils appear as prominent features at all observed levels of folding. These results are inconsistent with prevailing models of chromosome structure and, instead, suggest a folded chromonema model of chromosome structure.
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Cites
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Metadata
- Authors
- Belmont, A. S., & Bruce, K.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1994-10-15
- Volume
- 127
- Issue
- 2
- Pages
- 287-302
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2056216005
- Cited by
- 340
- References
- 20
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Belmont, A. S., & Bruce, K. (1994). Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure. The Journal of cell biology. https://doi.org/10.1083/jcb.127.2.287
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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