The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.
Open accessAbstract
The plasma protein fibronectin is an important opsonin in wound repair and host defense. To better understand the process of fibronectin-mediated phagocytosis, we have transfected K562 cells, which endogenously express alpha 5 beta 1, with alpha v beta 3. In these transfectants, antibodies to alpha v beta 3 block phagocytosis of fibronectin-opsonized beads completely, even though half the ingestion occurs through endogenous alpha 5 beta 1 receptors. alpha 5 beta 1-mediated adhesion to fibronectin-coated surfaces is unaffected by alpha v beta 3 ligation. Neither alpha v beta 5 nor alpha M beta 2 ligation affects alpha 5 beta 1 phagocytic function in transfectants expressing these receptors. Pharmacologic data suggest that alpha v beta 3 ligation suppresses the phagocytic competence of high affinity alpha 5 beta 1 receptors through a signal transduction pathway, perhaps involving protein kinase C. In addition to its significance for phagocytosis, alpha v beta 3 regulation of alpha 5 beta 1 function may be significant for its roles in cell migration, metastasis, and angiogenesis.
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Cites
Brown, E. J., & Goodwin, J. L. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.3.777 · Cited by 163
Self-citationZheleznyak, A., & Brown, E. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49803-7 · Cited by 118
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Cited by
Albert, M. L., Pearce, S. F. A., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., & Bhardwaj, N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1359 · Cited by 1,234
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
Phagocytosis and the actin cytoskeleton
May, R. C., & Machesky, L. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.6.1061 · Cited by 715
Phagocytosis: Our Current Understanding of a Universal Biological Process
Uribe-Querol, E., & Rosales, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01066 · Cited by 651
Adhesion events in angiogenesis
Eliceiri, B. P., & Cheresh, D. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00252-0 · Cited by 287
Metadata
- Authors
- Blystone, S. D., Graham, I. L., Lindberg, F. P., & Brown, E. J.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1994-11-15
- Volume
- 127
- Issue
- 4
- Pages
- 1129-1137
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2047196924
- Cited by
- 254
- References
- 2
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Blystone, S. D., Graham, I. L., Lindberg, F. P., & Brown, E. J. (1994). Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1. The Journal of cell biology. https://doi.org/10.1083/jcb.127.4.1129
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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