Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

Albert, Matthew L.; Pearce, S.Frieda A.; Francisco, Loise M.; Sauter, Birthe; Roy, Pampa; Silverstein, Roy L.; Bhardwaj, Nina

doi:10.1084/jem.188.7.1359

Cited by 1,234Immunotherapy and Immune ResponsesPhagocytosis and Immune RegulationImmune Response and Inflammation

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

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Albert, Matthew L., Pearce, S.Frieda A., Francisco, Loise M., Sauter, Birthe, Roy, Pampa, Silverstein, Roy L., Bhardwaj, Nina·1998·The Journal of Experimental Medicine

DOI 10.1084/jem.188.7.1359PMC PMC2212488

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Abstract

Dendritic cells, but not macrophages, efficiently phagocytose apoptotic cells and cross-present viral, tumor, and self-antigens to CD8+ T cells. This in vitro pathway corresponds to the in vivo phenomena of cross-priming and cross-tolerance. Here, we demonstrate that phagocytosis of apoptotic cells is restricted to the immature stage of dendritic cell (DC) development, and that this process is accompanied by the expression of a unique profile of receptors, in particular the αvβ5 integrin and CD36. Upon maturation, these receptors and, in turn, the phagocytic capacity of DCs, are downmodulated. Macrophages engulf apoptotic cells more efficiently than DCs, and although they express many receptors that mediate this uptake, they lack the αvβ5 integrin. Furthermore, in contrast to DCs, macrophages fail to cross-present antigenic material contained within the engulfed apoptotic cells. Thus, DCs use unique pathways for the phagocytosis, processing, and presentation of antigen derived from apoptotic cells on class I major histocompatibility complex. We suggest that the αvβ5 integrin plays a critical role in the trafficking of exogenous antigen by immature DCs in this cross-priming pathway.

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The long-term fate of CTLs is determined by additional signals from DCs, which must be licensed by prior CD40-CD40L interaction with activated CD4+ T cells.
“Following antigen recognition by CD8+ T cells and their development into CTLs, the long-term fate of these cells is determined by additional signals provided by DCs, which must be ‘licensed’ by a prior CD40–CD40L-mediated interaction with activated CD4+ T cells68.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [68]
Dendritic cells (DCs), a professional phagocytic cell type, can also identify and eradicate apoptotic cells.
“Dendritic cells (DCs), a professional phagocytic cell type, can also identify and eradicate apoptotic cells [160].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [160]

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Authors: Albert, M. L., Pearce, S. F. A., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., & Bhardwaj, N.
Affiliations: Cornell University (US)
Corresponding author: Bhardwaj, Nina
ORCID: Albert, Matthew L.
Francisco, Loise M.
Silverstein, Roy L.
Bhardwaj, Nina
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1998-10-05
Volume: 188
Issue: 7
Pages: 1359-1368
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.188.7.1359
PMC: PMC2212488
OpenAlex: W2053849689
Cited by: 1,234
References: 53
Citations by year: 2026: 8 · 2025: 5 · 2024: 19 · 2023: 11 · 2022: 12 · 2021: 16 · 2020: 38 · 2019: 13 · 2018: 17 · 2017: 19 · 2016: 24 · 2015: 18 · 2014: 33 · 2013: 27 · 2012: 40
FWCI: 29.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
HAL (submittedVersion)
HAL (submittedVersion, cc-by)
Funders: National Institutes of Health (5r01ey010967-08, 5r01hl042540-09)
National Heart, Lung, and Blood Institute (HL42540)
National Eye Institute (EY-10967)
National Institute of General Medical Sciences (GM07793)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: dendritic cells, phagocytosis of apoptotic cells, integrin αvβ5, CD36, dendritic cell maturation, cross-presentation, cross-priming, cytotoxic T lymphocytes, macrophages, receptor downmodulation
MeSH terms: CD83 Antigen, Cells, Cultured, Dendritic Cells, Humans, Immunoglobulins, Macrophages, Membrane Glycoproteins, Phagocytosis, T-Lymphocytes, Cytotoxic, Histocompatibility Antigens Class I, Antigens, CD, Integrins, Apoptosis, Antigen Presentation, CD36 Antigens, Receptors, Vitronectin

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Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

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