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Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.
Open accessAbstract
The role of the latent TGF-beta binding protein (LTBP) is unclear. In cultures of fetal rat calvarial cells, which form mineralized bonelike nodules, both LTBP and the TGF-beta 1 precursor localized to large fibrillar structures in the extracellular matrix. The appearance of these fibrillar structures preceded the appearance of type I collagen fibers. Plasmin treatment abolished the fibrillar staining pattern for LTBP and released a complex containing both LTBP and TGF-beta. Antibodies and antisense oligonucleotides against LTBP inhibited the formation of mineralized bonelike nodules in long-term fetal rat calvarial cultures. Immunohistochemistry of fetal and adult rat bone confirmed a fibrillar staining pattern for LTBP in vivo. These findings, together with the known homology of LTBP to the fibrillin family of proteins, suggest a novel function for LTBP, in addition to its role in matrix storage of latent TGF-beta, as a structural matrix protein that may play a role in bone formation.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
Metastasis to bone: causes, consequences and therapeutic opportunities
Mundy, G. R. (2002) · Nature Reviews Cancer · doi:10.1038/nrc867 · Cited by 2,777
Self-citationRoodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,755
Making sense of latent TGFβ activation
Annes, J. P., Munger, J. S., & Rifkin, D. B. (2003) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,628
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Self-citationFrom Cell–ECM interactions to tissue engineering
Rosso, F., Giordano, A., Barbarisi, M., & Barbarisi, A. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.10471 · Cited by 665
Metadata
- Authors
- Dallas, S. L., Miyazono, K., Skerry, T. M., Mundy, G. R., & Bonewald, L. F.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-10-15
- Volume
- 131
- Issue
- 2
- Pages
- 539-549
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1966170741
- Cited by
- 267
- References
- 1
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. https://app.cochat.ai/papers/10.1083/jcb.131.2.539
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- Dallas, S. L., Miyazono, K., Skerry, T. M., Mundy, G. R., & Bonewald, L. F. (1995). Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. The Journal of cell biology. https://doi.org/10.1083/jcb.131.2.539
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
