The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.
Open accessAbstract
The integrin heterodimer alpha 6 beta 4 is expressed in many epithelia and in Schwann cells. In stratified epithelia, alpha 6 beta 4 couple with BPAG1-e and BPAG2 to form hemidesmosomes, attaching externally to laminin and internally to the keratin cytoskeleton. To explore the function of this atypical integrin, and its relation to conventional actin-associated integrins, we targeted the removal of the beta 4 gene in mice. Tissues that express alpha 6 beta 4 are grossly affected. Stratified tissues are devoid of hemidesmosomes, display only a very fragile attachment to the basal lamina, and exhibit signs of degeneration and tissue disorganization. Simple epithelia which express alpha 6 beta 4 are also defective in adherence, even though they do not form hemidesmosomes. In the absence of beta 4, alpha 6 is dramatically downregulated, and other integrins do not appear to compensate for the loss of this heterodimer. These data have important implications for understanding integrin function in cell-substratum adhesion, cell survival and differentiation, and for understanding the role of alpha 6 beta 4 in junctional epidermolysis bullosa, an often lethal human disorder with pathology similar to our mice.
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Cites
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Metadata
- Authors
- Dowling, J., Yu, Q. C., & Fuchs, E.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-07-15
- Volume
- 134
- Issue
- 2
- Pages
- 559-572
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2142942121
- Cited by
- 507
- References
- 34
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dowling, J., Yu, Q. C., & Fuchs, E. (1996). Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. The Journal of cell biology. https://doi.org/10.1083/jcb.134.2.559
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