An Essential Role for Katanin in Severing Microtubules in the Neuron
Open accessAbstract
Several lines of evidence suggest that microtubules are nucleated at the neuronal centrosome, and then released for transport into axons and dendrites. Here we sought to determine whether the microtubule-severing protein known as katanin mediates microtubule release from the neuronal centrosome. Immunomicroscopic analyses on cultured sympathetic neurons show that katanin is present at the centrosome, but is also widely distributed throughout the neuron. Microinjection of an antibody that inactivates katanin results in a dramatic accumulation of microtubules at the centrosome, indicating that katanin is indeed required for microtubule release from the centrosome. However, the antibody also causes an inhibition of axon outgrowth that is more immediate than expected on this basis alone. It may be that katanin severs microtubules throughout the cell body to keep them sufficiently short to be efficiently transported into developing processes. Consistent with this idea, there were significantly fewer free ends of microtubules in the cell bodies of neurons that had been injected with the katanin antibody compared with controls. These results indicate that microtubule-severing by katanin is essential for releasing microtubules from the neuronal centrosome, and also for regulating the length of the microtubules after their release.
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Some microtubule-related genes associated with axonal transport and known to play a role in post-mitotic neural wiring and plasticity are associated with signals of positive selection, such as KIF18A or KATNA1.
“Some of the aforementioned microtubule-related genes, specifically those associated with axonal transport and known to play a role in post-mitotic neural wiring and plasticity93, are associated with signals of positive selection, such as KIF18A94 or KATNA195,96.”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [95]
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- Authors
- Ahmad, F. J., Yu, W., McNally, F. J., & Baas, P. W.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Yu, Wenqian
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-04-19
- Volume
- 145
- Issue
- 2
- Pages
- 305-315
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2133110
- OpenAlex
- W2066803550
- Cited by
- 253
- References
- 21
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 14
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- katanin, microtubule severing, axon growth, microtubule length regulation, microtubule transport, sympathetic neurons, microtubule ends
- MeSH terms
- Katanin, Adenosine Triphosphatases, Animals, Animals, Newborn, Axons, Cells, Cultured, Ganglia, Sympathetic, Microscopy, Electron, Microtubules, Neurons, Trimethoprim, Sulfamethoxazole Drug Combination, Microscopy, Immunoelectron, Centrosome, Rats
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