The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rac Homologues and Compartmentalized Phosphatidylinositol 4, 5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen Tube Growth
Open accessAbstract
Pollen tube cells elongate based on actin- dependent targeted secretion at the tip. Rho family small GTPases have been implicated in the regulation of related processes in animal and yeast cells. We have functionally characterized Rac type Rho family proteins that are expressed in growing pollen tubes. Expression of dominant negative Rac inhibited pollen tube elongation, whereas expression of constitutive active Rac induced depolarized growth. Pollen tube Rac was found to accumulate at the tip plasma membrane and to physically associate with a phosphatidylinositol monophosphate kinase (PtdIns P-K) activity. Phosphatidylinositol 4, 5-bisphosphate (PtdIns 4, 5-P2), the product of PtdIns P-Ks, showed a similar intracellular localization as Rac. Expression of the pleckstrin homology (PH)-domain of phospholipase C (PLC)-δ1, which binds specifically to PtdIns 4, 5-P2, inhibited pollen tube elongation. These results indicate that Rac and PtdIns 4, 5-P2 act in a common pathway to control polar pollen tube growth and provide direct evidence for a function of PtdIns 4, 5-P2 compartmentalization in the regulation of this process.
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Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
Lemmon, M. A., Ferguson, K. M., O'Brien, R., Sigler, P. B., & Schlessinger, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10472 · Cited by 566
Li, H., Wu, G., Ware, D., Davis, K. R., & Yang, Z. (1998) · Plant Physiology · doi:10.1104/pp.118.2.407 · Cited by 194 · cited 3×
“The protein sequences of Arac1 (Winge et al., 1997) and Rop1At (Li et al., 1998), two A. thaliana Rac-like proteins that share very high sequence homology with At-Rac2 (98.5 and 95.4% identical amino acids, respectively), are shown in Fig.”
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Cited by
Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth
Molendijk, A. J., Bischoff, F., Rajendrakumar, C. S. V., Friml, J., Braun, M., Gilroy, S., & Palme, K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2779 · Cited by 439
Function and regulation of phospholipid signalling in plants
Xue, H.-W., Chen, X., & Mei, Y. (2009) · Biochemical Journal · doi:10.1042/bj20090300 · Cited by 219
Structure, function and membrane interactions of plant annexins: An update
Konopka-Postupolska, D., Clark, G., & Hofmann, A. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.05.013 · Cited by 94
Dahhan, D. A., Reynolds, G. D., Cárdenas, J. J., Eeckhout, D., Johnson, A., Yperman, K., Kaufmann, W. A., Vang, N., Yan, X., Hwang, I., et al. (2022) · The Plant Cell · doi:10.1093/plcell/koac071 · Cited by 54
Ruan, J., Lai, L., Ou, H., & Yi, P. (2023) · Nature Communications · doi:10.1038/s41467-023-42879-y · Cited by 23
Metadata
- Authors
- Kost, B., Lemichez, E., Spielhofer, P., Hong, Y., Tolias, K., Carpenter, C., & Chua, N.-H.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-04-19
- Volume
- 145
- Issue
- 2
- Pages
- 317-330
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1990134601
- Cited by
- 561
- References
- 3
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Rac Homologues and Compartmentalized Phosphatidylinositol 4, 5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen Tube Growth. https://app.cochat.ai/papers/10.1083/jcb.145.2.317
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- Kost, B., Lemichez, E., Spielhofer, P., Hong, Y., Tolias, K., Carpenter, C., & Chua, N.-H. (1999). Rac Homologues and Compartmentalized Phosphatidylinositol 4, 5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen Tube Growth. The Journal of Cell Biology. https://doi.org/10.1083/jcb.145.2.317
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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