The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oxygen Stress: A Regulator of Apoptosis in Yeast
Open accessAbstract
Oxygen radicals are important components of metazoan apoptosis. We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H2O2. Cycloheximide prevents apoptotic death revealing active participation of the cell. Yeast can also be triggered into apoptosis by a mutation in CDC48 or by expression of mammalian bax. In both cases, we show oxygen radicals to accumulate in the cell, whereas radical depletion or hypoxia prevents apoptosis. These results suggest that the generation of oxygen radicals is a key event in the ancestral apoptotic pathway and offer an explanation for the mechanism of bax-induced apoptosis in the absence of any established apoptotic gene in yeast.
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Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
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Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
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Experimental evolution of multicellularity
Ratcliff, W. C., Denison, R. F., Borrello, M., & Travisano, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115323109 · Cited by 570
Lewis, K. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.503-514.2000 · Cited by 616
Chronological aging leads to apoptosis in yeast
Herker, E., Jungwirth, H., Lehmann, K. A., Maldener, C., Fröhlich, K.-U., Wissing, S., Büttner, S., Fehr, M., Sigrist, S., & Madeo, F. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310014 · Cited by 548
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Metadata
- Authors
- Madeo, F., Fröhlich, E., Ligr, M., Grey, M., Sigrist, S. J., Wolf, D. H., & Fröhlich, K.-U.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-05-17
- Volume
- 145
- Issue
- 4
- Pages
- 757-767
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2121702473
- Cited by
- 1,015
- References
- 1
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Madeo, F., Fröhlich, E., Ligr, M., Grey, M., Sigrist, S. J., Wolf, D. H., & Fröhlich, K.-U. (1999). Oxygen Stress: A Regulator of Apoptosis in Yeast. The Journal of Cell Biology. https://doi.org/10.1083/jcb.145.4.757
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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