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Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton
Open accessAbstract
T cell receptor (TCR)-driven activation of helper T cells induces a rapid polarization of their cytoskeleton towards bound antigen presenting cells (APCs). We have identified the Fyn- and SLP-76–associated protein Fyb/SLAP as a new ligand for Ena/ vasodilator-stimulated phosphoprotein (VASP) homology 1 (EVH1) domains. Upon TCR engagement, Fyb/SLAP localizes at the interface between T cells and anti-CD3–coated beads, where Evl, a member of the Ena/VASP family, Wiskott-Aldrich syndrome protein (WASP) and the Arp2/3 complex are also found. In addition, Fyb/SLAP is restricted to lamellipodia of spreading platelets. In activated T cells, Fyb/SLAP associates with Ena/VASP family proteins and is present within biochemical complexes containing WASP, Nck, and SLP-76. Inhibition of binding between Fyb/SLAP and Ena/VASP proteins or WASP and the Arp2/3 complex impairs TCR-dependent actin rearrangement, suggesting that these interactions play a key role in linking T cell signaling to remodeling of the actin cytoskeleton.
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Self-citationEstin, M. L., Thompson, S. B., Traxinger, B., Fisher, M. H., Friedman, R. S., & Jacobelli, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701886114 · Cited by 45
Metadata
- Authors
- Krause, M., Sechi, A. S., Konradt, M., Monner, D., Gertler, F. B., & Wehland, J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-04-03
- Volume
- 149
- Issue
- 1
- Pages
- 181-194
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2071442472
- Cited by
- 296
- References
- 0
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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