The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
Open accessAbstract
Disruption of the function of the A-type Aurora kinase of Drosophila by mutation or RNAi leads to a reduction in the length of astral microtubules in syncytial embryos, larval neuroblasts, and cultured S2 cells. In neuroblasts, it can also lead to loss of an organized centrosome and its associated aster from one of the spindle poles, whereas the centrosome at the other pole has multiple centrioles. When centrosomes are present at the poles of aurA mutants or aurA RNAi spindles, they retain many antigens but are missing the Drosophila counterpart of mammalian transforming acidic coiled coil (TACC) proteins, D-TACC. We show that a subpopulation of the total Aurora A is present in a complex with D-TACC, which is a substrate for the kinase. We propose that one of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 microtubule-associated protein may be recruited, and thus modulate the behavior of astral microtubules.
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Blangy, A., Lane, H. A., d'Hérin, P., Harper, M., Kress, M., & Niggt, E. A. (1995) · Cell · doi:10.1016/0092-8674(95)90142-6 · Cited by 952
Giet, R., Uzbekov, R., Cubizolles, F., Le Guellec, K., & Prigent, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15005 · Cited by 219
Self-citation
Cited by
Harrington, E. A., Bebbington, D., Moore, J., Rasmussen, R. K., Ajose-Adeogun, A. O., Nakayama, T., Graham, J. A., Demur, C., Hercend, T., Diu-Hercend, A., et al. (2004) · Nature Medicine · doi:10.1038/nm1003 · Cited by 965
Shared and separate functions of polo-like kinases and aurora kinases in cancer
Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2964 · Cited by 597
Aurora A kinase (AURKA) in normal and pathological cell division
Nikonova, A. S., Astsaturov, I., Serebriiskii, I. G., Dunbrack, R. L., & Golemis, E. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1073-7 · Cited by 448
Aurora-A: the maker and breaker of spindle poles
Barr, A. R., & Gergely, F. (2007) · Journal of Cell Science · doi:10.1242/jcs.013136 · Cited by 441
Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions
Hubner, N. C., Bird, A. W., Cox, J., Splettstoesser, B., Bandilla, P., Poser, I., Hyman, A., & Mann, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911091 · Cited by 440
Metadata
- Authors
- Giet, R., McLean, D., Descamps, S., Lee, M. J., Raff, J. W., Prigent, C., & Glover, D. M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-02-04
- Volume
- 156
- Issue
- 3
- Pages
- 437-451
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2008609502
- Cited by
- 331
- References
- 2
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Giet, R., McLean, D., Descamps, S., Lee, M. J., Raff, J. W., Prigent, C., & Glover, D. M. (2002). Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200108135
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