The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
Open accessAbstract
The axon initial segment is an excitable membrane highly enriched in voltage-gated sodium channels that integrates neuronal inputs and initiates action potentials. This study identifies Nav1.6 as the voltage-gated sodium channel isoform at mature Purkinje neuron initial segments and reports an essential role for ankyrin-G in coordinating the physiological assembly of Nav1.6, βIV spectrin, and the L1 cell adhesion molecules (L1 CAMs) neurofascin and NrCAM at initial segments of cerebellar Purkinje neurons. Ankyrin-G and βIV spectrin appear at axon initial segments by postnatal day 2, whereas L1 CAMs and Nav1.6 are not fully assembled at continuous high density along axon initial segments until postnatal day 9. L1 CAMs and Nav1.6 therefore do not initiate protein assembly at initial segments. βIV spectrin, Nav1.6, and L1 CAMs are not clustered in adult Purkinje neuron initial segments of mice lacking cerebellar ankyrin-G. These results support the conclusion that ankyrin-G coordinates the physiological assembly of a protein complex containing transmembrane adhesion molecules, voltage-gated sodium channels, and the spectrin membrane skeleton at axon initial segments.
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Cites
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Self-citationSodium channel Na v 1.6 is localized at nodes of Ranvier, dendrites, and synapses
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Self-citationCompact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same Axon
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A diffusion barrier maintains distribution of membrane proteins in polarized neurons
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Self-citationDependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
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Self-citationCalcium Absorption Across Epithelia
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Pan, Z., Kao, T., Horvath, Z., Lemos, J., Sul, J.-Y., Cranstoun, S. D., Bennett, V., Scherer, S. S., & Cooper, E. C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4314-05.2006 · Cited by 585
Self-citationThe axon initial segment and the maintenance of neuronal polarity
Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442
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Metadata
- Authors
- Jenkins, S. M., & Bennett, V.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2001-11-26
- Volume
- 155
- Issue
- 5
- Pages
- 739-746
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2142703154
- Cited by
- 444
- References
- 25
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Jenkins, S. M., & Bennett, V. (2001). Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200109026
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