The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Force transduction by Triton cytoskeletons
Open accessAbstract
Force-initiated signal transduction can occur either via membrane-based ionic mechanisms or through changes in cytoskeletal–matrix linkages. We report here the stretch-dependent binding of cytoplasmic proteins to Triton X-100 cytoskeletons of L-929 cells grown on collagen-coated silicone. Triton X-100–insoluble cytoskeletons were stretched by 10% and incubated with biotinylated cytoplasmic proteins. Analysis with two-dimensional gel electrophoresis showed stretch-dependent binding of more than 10 cytoplasmic protein spots. Bound cytoplasmic proteins were purified by a photocleavable biotin tag and stretch-dependent binding of paxillin, focal adhesion kinase, and p130Cas was found, whereas the binding of vinculin was unchanged and actin binding decreased with stretch. Paxillin binding upon stretch was morphologically and biochemically similar in vitro and in vivo, that is, enhanced in the periphery and inhibited by the tyrosine phosphatase inhibitor, phenylarsine oxide. Thus, we suggest that transduction of matrix forces occurs through force-dependent conformation changes in the integrated cytoskeleton.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,657
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M., & Fukami, Y. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45614-1 · Cited by 3,724
Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
Wang, N., Butler, J. P., & Ingber, D. E. (1993) · Science · doi:10.1126/science.7684161 · Cited by 3,003
Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S., Bershadsky, A., Addadi, L., et al. (2001) · Nature Cell Biology · doi:10.1038/35074532 · Cited by 2,132
Focal Contacts as Mechanosensors
Riveline, D., Zamir, E., Balaban, N. Q., Schwarz, U. S., Ishizaki, T., Narumiya, S., Kam, Z., Geiger, B., & Bershadsky, A. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1175 · Cited by 1,419
Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages
Choquet, D., Felsenfeld, D. P., & Sheetz, M. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81856-5 · Cited by 1,245
Self-citationCalcium Mobilization and Exocytosis After One Mechanical Stretch of Lung Epithelial Cells
Wirtz, H. R. W., & Dobbs, L. G. (1990) · Science · doi:10.1126/science.2173861 · Cited by 511
Grill, S. W., Gönczy, P., Stelzer, E. H. K., & Hyman, A. A. (2001) · Nature · doi:10.1038/35054572 · Cited by 509
King, W. G., Mattaliano, M. D., Chan, T. O., Tsichlis, P. N., & Brugge, J. S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4406 · Cited by 425
Cited by
Dynamic molecular processes mediate cellular mechanotransduction
Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011) · Nature · doi:10.1038/nature10316 · Cited by 956
Adhesion-Dependent Cell Mechanosensitivity
Bershadsky, A. D., Balaban, N. Q., & Geiger, B. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153011 · Cited by 874
Genetic and cell biological analysis of integrin outside-in signaling
Legate, K. R., Wickström, S. A., & Fässler, R. (2009) · Genes & Development · doi:10.1101/gad.1758709 · Cited by 802
Appreciating force and shape—the rise of mechanotransduction in cell biology
Iskratsch, T., Wolfenson, H., & Sheetz, M. P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3903 · Cited by 798
Self-citationThe myofibroblast: Paradigm for a mechanically active cell
Hinz, B. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 698
Metadata
- Authors
- Sawada, Y., & Sheetz, M. P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-02-11
- Volume
- 156
- Issue
- 4
- Pages
- 609-615
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1986120913
- Cited by
- 289
- References
- 28
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Force transduction by Triton cytoskeletons. https://app.cochat.ai/papers/10.1083/jcb.200110068
- The paper
- Sawada, Y., & Sheetz, M. P. (2002). Force transduction by Triton cytoskeletons. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200110068
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
