The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction
Open accessAbstract
Microtubule-associated protein 2 (MAP2) is a major component of cross-bridges between microtubules in dendrites, and is known to stabilize microtubules. MAP2 also has a binding domain for the regulatory subunit II of cAMP-dependent protein kinase (PKA). We found that there is reduction in microtubule density in dendrites and a reduction of dendritic length in MAP2-deficient mice. Moreover, there is a significant reduction of various subunits of PKA in dendrites and total amounts of various PKA subunits in hippocampal tissue and cultured neurons. In MAP2-deficient cultured neurons, the induction rate of phosphorylated CREB after forskolin stimulation was much lower than in wild-type neurons. Therefore, MAP2 is an anchoring protein of PKA in dendrites, whose loss leads to reduced amount of dendritic and total PKA and reduced activation of CREB.
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Self-citationGolgi Vesiculation and Lysosome Dispersion in Cells Lacking Cytoplasmic Dynein
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The Rab8 GTPase regulates apical protein localization in intestinal cells
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Metadata
- Authors
- Harada, A., Teng, J., Takei, Y., Oguchi, K., & Hirokawa, N.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-08-05
- Volume
- 158
- Issue
- 3
- Pages
- 541-549
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2024791530
- Cited by
- 366
- References
- 25
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
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