The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system
Open accessAbstract
Growth inhibitory proteins in the central nervous system (CNS) block axon growth and regeneration by signaling to Rho, an intracellular GTPase. It is not known how CNS trauma affects the expression and activation of RhoA. Here we detect GTP-bound RhoA in spinal cord homogenates and report that spinal cord injury (SCI) in both rats and mice activates RhoA over 10-fold in the absence of changes in RhoA expression. In situ Rho-GTP detection revealed that both neurons and glial cells showed Rho activation at SCI lesion sites. Application of a Rho antagonist (C3–05) reversed Rho activation and reduced the number of TUNEL-labeled cells by ∼50% in both injured mouse and rat, showing a role for activated Rho in cell death after CNS injury. Next, we examined the role of the p75 neurotrophin receptor (p75NTR) in Rho signaling. After SCI, an up-regulation of p75NTR was detected by Western blot and observed in both neurons and glia. Treatment with C3–05 blocked the increase in p75NTR expression. Experiments with p75NTR-null mutant mice showed that immediate Rho activation after SCI is p75NTR dependent. Our results indicate that blocking overactivation of Rho after SCI protects cells from p75NTR-dependent apoptosis.
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Cites
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Temporal–Spatial Pattern of Acute Neuronal and Glial Loss after Spinal Cord Contusion
Grossman, S. D., Rosenberg, L. J., & Wrathall, J. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7628 · Cited by 310
Rho signals to cell growth and apoptosis
Aznar, S., & Lacal, J. C. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00412-8 · Cited by 310
Cited by
Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets
Ng, S. Y., & Lee, A. Y. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00528 · Cited by 852
Rho kinase, a promising drug target for neurological disorders
Mueller, B. K., Mack, H., & Teusch, N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1719 · Cited by 608
Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice
Goldshmit, Y., Galea, M. P., Wise, G., Bartlett, P. F., & Turnley, A. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2981-04.2004 · Cited by 317
Enhancement on Primate Corneal Endothelial Cell Survival In Vitro by a ROCK Inhibitor
Okumura, N., Ueno, M., Koizumi, N., Sakamoto, Y., Hirata, K., Hamuro, J., & Kinoshita, S. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-2634 · Cited by 300
RGMa inhibition promotes axonal growth and recovery after spinal cord injury
Hata, K., Fujitani, M., Yasuda, Y., Doya, H., Saito, T., Yamagishi, S., Mueller, B. K., & Yamashita, T. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508143 · Cited by 289
Metadata
- Authors
- Dubreuil, C. I., Winton, M. J., & McKerracher, L.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-07-08
- Volume
- 162
- Issue
- 2
- Pages
- 233-243
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2020122922
- Cited by
- 397
- References
- 3
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- green
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