The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
RGMa inhibition promotes axonal growth and recovery after spinal cord injury
Open accessAbstract
Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of the RhoA–Rho kinase pathway. RGMa expression is observed in oligodendrocytes, myelinated fibers, and neurons of the adult rat spinal cord and is induced around the injury site after spinal cord injury. We developed an antibody to RGMa that efficiently blocks the effect of RGMa in vitro. Intrathecal administration of the antibody to rats with thoracic spinal cord hemisection results in significant axonal growth of the corticospinal tract and improves functional recovery. Thus, RGMa plays an important role in limiting axonal regeneration after CNS injury and the RGMa antibody offers a possible therapeutic agent in clinical conditions characterized by a failure of CNS regeneration.
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Cites
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Nogo-66 receptor antagonist peptide promotes axonal regeneration
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“Double staining using anti-RGMa and anti– myelin/oligodendrocyte-specifi c protein (MOSP) antibodies (Dyer et al., 1991; Beck et al., 1995) showed that RGMa was expressed in oligodendrocyte cell bodies and their processes in the white matter (Fig.”
MethodRho kinase, a promising drug target for neurological disorders
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Self-citation
Cited by
Repertoire of microglial and macrophage responses after spinal cord injury
David, S., & Kroner, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3053 · Cited by 1,297
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Lingor, P., Teusch, N., Schwarz, K., Mueller, R., Mack, H., Bähr, M., & Mueller, B. K. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04756.x · Cited by 214
Self-citationRGMs: Structural Insights, Molecular Regulation, and Downstream Signaling
Siebold, C., Yamashita, T., Monnier, P. P., Mueller, B. K., & Pasterkamp, R. J. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.009 · Cited by 118
Self-citationTargeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, D., Martins, I., Cristóvão, A. M., Dias, A. F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A., & Saúde, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109334 · Cited by 74
Metadata
- Authors
- Hata, K., Fujitani, M., Yasuda, Y., Doya, H., Saito, T., Yamagishi, S., Mueller, B. K., & Yamashita, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-04-03
- Volume
- 173
- Issue
- 1
- Pages
- 47-58
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1983729552
- Cited by
- 289
- References
- 33
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Hata, K., Fujitani, M., Yasuda, Y., Doya, H., Saito, T., Yamagishi, S., Mueller, B. K., & Yamashita, T. (2006). RGMa inhibition promotes axonal growth and recovery after spinal cord injury. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200508143
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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