The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice
Open accessAbstract
Spinal cord injury usually results in permanent paralysis because of lack of regrowth of damaged neurons. Here we demonstrate that adult mice lacking EphA4 (-/-), a molecule essential for correct guidance of spinal cord axons during development, exhibit axonal regeneration and functional recovery after spinal cord hemisection. Anterograde and retrograde tracing showed that axons from multiple pathways, including corticospinal and rubrospinal tracts, crossed the lesion site. EphA4-/- mice recovered stride length, the ability to walk on and climb a grid, and the ability to grasp with the affected hindpaw within 1-3 months of injury. EphA4 expression was upregulated on astrocytes at the lesion site in wild-type mice, whereas astrocytic gliosis and the glial scar were greatly reduced in lesioned EphA4-/- spinal cords. EphA4-/- astrocytes failed to respond to the inflammatory cytokines, interferon-γ or leukemia inhibitory factor, in vitro . Neurons grown on wild-type astrocytes extended shorter neurites than on EphA4-/- astrocytes, but longer neurites when the astrocyte EphA4 was blocked by monomeric EphrinA5-Fc. Thus, EphA4 regulates two important features of spinal cord injury, axonal inhibition, and astrocytic gliosis.
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Cited by
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects
Karimi-Abdolrezaee, S., & Billakanti, R. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8287-4 · Cited by 331
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
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Use of polysialic acid in repair of the central nervous system
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Metadata
- Authors
- Goldshmit, Y., Galea, M. P., Wise, G., Bartlett, P. F., & Turnley, A. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-11-10
- Volume
- 24
- Issue
- 45
- Pages
- 10064-10073
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2020850411
- Cited by
- 317
- References
- 55
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Goldshmit, Y., Galea, M. P., Wise, G., Bartlett, P. F., & Turnley, A. M. (2004). Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2981-04.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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