Cited by 170Neurogenesis and neuroplasticity mechanismsCell Adhesion Molecules ResearchMultiple Sclerosis Research Studies

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Integrin-linked kinase is required for laminin-2–induced oligodendrocyte cell spreading and CNS myelination

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Chun, Soo Jin, Rasband, Matthew N., Sidman, Richard L., Habib, Amyn A., Vartanian, Timothy·2003·The Journal of Cell Biology

DOI 10.1083/jcb.200304154PMC PMC2173507

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Abstract

Early steps in myelination in the central nervous system (CNS) include a specialized and extreme form of cell spreading in which oligodendrocytes extend large lamellae that spiral around axons to form myelin. Recent studies have demonstrated that laminin-2 (LN-2; α2β1γ1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin α6β1. Although a congenital LN-2 deficiency in humans is associated with CNS white matter changes, LN-2–deficient (dy/dy) mice have shown abnormalities primarily within the peripheral nervous system. Here, we demonstrate a critical role for LN-2 in CNS myelination by showing that dy/dy mice have quantitative and morphologic defects in CNS myelin. We have defined the molecular pathway through which LN-2 signals oligodendrocyte cell spreading by demonstrating requirements for phosphoinositide 3-kinase activity and integrin-linked kinase (ILK). Interaction of oligodendrocytes with LN-2 stimulates ILK activity. A dominant negative ILK inhibits LN-2–induced myelinlike membrane formation. A critical component of the myelination signaling cascade includes LN-2 and integrin signals through ILK.

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Authors: Chun, S. J., Rasband, M. N., Sidman, R. L., Habib, A. A., & Vartanian, T.
Affiliations: Beth Israel Deaconess Medical Center (US)
UConn Health (US)
Corresponding author: Vartanian, Timothy
ORCID: Rasband, Matthew N.
Sidman, Richard L.
Habib, Amyn A.
Vartanian, Timothy
Venue: The Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 2003-10-27
Volume: 163
Issue: 2
Pages: 397-408
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.200304154
PMC: PMC2173507
OpenAlex: W2120316837
Cited by: 170
References: 41
Citations by year: 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 7 · 2012: 8
FWCI: 2.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k02ns002028-04)
National Institute of Neurological Disorders and Stroke (K02 NS02028, P01 NS 38475, R01NS044916, P01NS038475, R01NS042317, R01 NS42317)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: integrin-linked kinase, laminin-2, CNS myelination, alpha6beta1 integrin, phosphatidylinositol 3-kinase, myelination, integrin signaling
MeSH terms: Scaffold Protein ILK, Adenoviridae, Animals, Axons, Cell Survival, Cells, Cultured, Central Nervous System, Cytoskeletal Proteins, Enzyme Activation, Homozygote, Laminin, Mice, Mutant Strains, Mutation, Myelin Sheath, Oligodendroglia, Optic Nerve, Phosphoproteins, Cell Adhesion Molecules, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases, Phosphatidylinositol 3-Kinases, Mice, Rats, Paxillin

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Integrin-linked kinase is required for laminin-2–induced oligodendrocyte cell spreading and CNS myelination

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