The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector
Open accessAbstract
The small guanosine triphosphate (GTP)–binding protein ADP-ribosylation factor (ARF) 6 regulates membrane recycling to regions of plasma membrane remodeling via the endocytic pathway. Here, we show that GTP–bound ARF6 interacts with Sec10, a subunit of the exocyst complex involved in docking of vesicles with the plasma membrane. We found that Sec10 localization in the perinuclear region is not restricted to the trans-Golgi network, but extends to recycling endosomes. In addition, we report that depletion of Sec5 exocyst subunit or dominant inhibition of Sec10 affects the function and the morphology of the recycling pathway. Sec10 is found to redistribute to ruffling areas of the plasma membrane in cells expressing GTP-ARF6, whereas dominant inhibition of Sec10 interferes with ARF6-induced cell spreading. Our paper suggests that ARF6 specifies delivery and insertion of recycling membranes to regions of dynamic reorganization of the plasma membrane through interaction with the vesicle-tethering exocyst complex.
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Cites
The exocyst is a Ral effector complex
Moskalenko, S., Henry, D. O., Rosse, C., Mirey, G., Camonis, J. H., & White, M. A. (2002) · Nature Cell Biology · doi:10.1038/ncb728 · Cited by 423
Self-citationDaro, E., van der Sluijs, P., Galli, T., & Mellman, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9559 · Cited by 343
Cdc42 Interacts with the Exocyst and Regulates Polarized Secretion
Zhang, X., Bi, E., Novick, P., Du, L., Kozminski, K. G., Lipschutz, J. H., & Guo, W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107464200 · Cited by 307
The Brain Exocyst Complex Interacts with RalA in a GTP-dependent Manner
Brymora, A., Valova, V. A., Larsen, M. R., Roufogalis, B. D., & Robinson, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100320200 · Cited by 143
Cited by
Pathways and mechanisms of endocytic recycling
Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,424
ARF proteins: roles in membrane traffic and beyond
D'Souza-Schorey, C., & Chavrier, P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1910 · Cited by 1,378
Self-citationHuman RAS Superfamily Proteins and Related GTPases
Colicelli, J. (2004) · Science's STKE · doi:10.1126/stke.2502004re13 · Cited by 582
The exocyst complex in polarized exocytosis
He, B., & Guo, W. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.04.007 · Cited by 438
Wang, J., Ding, Y., Wang, J., Hillmer, S., Miao, Y., Lo, S. W., Wang, X., Robinson, D. G., & Jiang, L. (2011) · The Plant Cell · doi:10.1105/tpc.110.080697 · Cited by 357
Metadata
- Authors
- Prigent, M., Dubois, T., Raposo, G., Derrien, V., Tenza, D., Rossé, C., Camonis, J., & Chavrier, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-12-08
- Volume
- 163
- Issue
- 5
- Pages
- 1111-1121
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2115410053
- Cited by
- 217
- References
- 4
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Prigent, M., Dubois, T., Raposo, G., Derrien, V., Tenza, D., Rossé, C., Camonis, J., & Chavrier, P. (2003). ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200305029
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