The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors
Open accessAbstract
Ca2+ release from the envelope of isolated pancreatic acinar nuclei could be activated by nicotinic acid adenine dinucleotide phosphate (NAADP) as well as by inositol 1,4,5-trisphosphate (IP3) and cyclic ADP-ribose (cADPR). Each of these agents reduced the Ca2+ concentration inside the nuclear envelope, and this was associated with a transient rise in the nucleoplasmic Ca2+ concentration. NAADP released Ca2+ from the same thapsigargin-sensitive pool as IP3. The NAADP action was specific because, for example, nicotineamide adenine dinucleotide phosphate was ineffective. The Ca2+ release was unaffected by procedures interfering with acidic organelles (bafilomycin, brefeldin, and nigericin). Ryanodine blocked the Ca2+-releasing effects of NAADP, cADPR, and caffeine, but not IP3. Ruthenium red also blocked the NAADP-elicited Ca2+ release. IP3 receptor blockade did not inhibit the Ca2+ release elicited by NAADP or cADPR. The nuclear envelope contains ryanodine and IP3 receptors that can be activated separately and independently; the ryanodine receptors by either NAADP or cADPR, and the IP3 receptors by IP3.
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Pinton, P., Pozzan, T., & Rizzuto, R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5298 · Cited by 435 · cited 2×
“…2002), whereas the function and importance of Ca 2 release from the nuclear envelope (Malviya et al., 1990; Nicotera et al., 1990; Gerasimenko et al., 1995), the Golgi apparatus (Pinton et al., 1998), the secretory granules (Yoo, 2000), and the endosomes (Gerasimenko et al., 1998) are less clear.”
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Cited by
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2006) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,206
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862
NAADP mobilizes calcium from acidic organelles through two-pore channels
Calcraft, P. J., Ruas, M., Pan, Z., Cheng, X., Arredouani, A., Hao, X., Tang, J., Rietdorf, K., Teboul, L., Chuang, K.-T., et al. (2009) · Nature · doi:10.1038/nature08030 · Cited by 760
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
Brailoiu, E., Churamani, D., Cai, X., Schrlau, M. G., Brailoiu, G. C., Gao, X., Hooper, R., Boulware, M. J., Dun, N. J., Marchant, J. S., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200904073 · Cited by 401
Metadata
- Authors
- Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H., & Gerasimenko, O. V.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-10-20
- Volume
- 163
- Issue
- 2
- Pages
- 271-282
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2069945478
- Cited by
- 222
- References
- 2
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. https://app.cochat.ai/papers/10.1083/jcb.200306134
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- Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H., & Gerasimenko, O. V. (2003). NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200306134
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