The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
Open accessAbstract
Integral proteins in the outer membrane of mitochondria control all aspects of organelle biogenesis, being required for protein import, mitochondrial fission, and, in metazoans, mitochondrial aspects of programmed cell death. How these integral proteins are assembled in the outer membrane had been unclear. In bacteria, Omp85 is an essential component of the protein insertion machinery, and we show that members of the Omp85 protein family are also found in eukaryotes ranging from plants to humans. In eukaryotes, Omp85 is present in the mitochondrial outer membrane. The gene encoding Omp85 is essential for cell viability in yeast, and conditional omp85 mutants have defects that arise from compromised insertion of integral proteins like voltage-dependent anion channel (VDAC) and components of the translocase in the outer membrane of mitochondria (TOM) complex into the mitochondrial outer membrane.
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Mitochondrial protein import: from proteomics to functional mechanisms
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The Protein Import Machinery of Mitochondria
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Metadata
- Authors
- Gentle, I., Gabriel, K., Beech, P., Waller, R., & Lithgow, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-12-29
- Volume
- 164
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2081866213
- Cited by
- 373
- References
- 39
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
