The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
Open accessAbstract
Transforming growth factor-βs (TGF-β) are secreted as inactive complexes containing the TGF-β, the TGF-β propeptide, also called the latency-associated protein (LAP), and the latent TGF-β binding protein (LTBP). Extracellular activation of this complex is a critical but incompletely understood step in TGF-β regulation. We have investigated the role of LTBP in modulating TGF-β generation by the integrin αVβ6. We show that even though αvβ6 recognizes an RGD on LAP, LTBP-1 is required for αVβ6-mediated latent TGF-β activation. The domains of LTBP-1 necessary for activation include the TGF-β propeptide-binding domain and a basic amino acid sequence (hinge domain) with ECM targeting properties. Our results demonstrate an LTBP-1 isoform-specific function in αVβ6-mediated latent TGF-β activation; LTBP-3 is unable to substitute for LTBP-1 in this assay. The results reveal a functional role for LTBP-1 in latent TGF-β activation and suggest that activation of specific latent complexes is regulated by distinct mechanisms that may be determined by the LTBP isoform and its potential interaction with the matrix.
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Cites
Abe, M., Harpel, J. G., Metz, C. N., Nunes, I., Loskutoff, D. J., & Rifkin, D. B. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1042 · Cited by 757
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Metadata
- Authors
- Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-06-07
- Volume
- 165
- Issue
- 5
- Pages
- 723-734
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2018822666
- Cited by
- 499
- References
- 1
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004). Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200312172
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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