The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
Open accessAbstract
Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear. Thus, we examined epithelial polarity establishment during early Drosophila development. We found apical accumulation of both Drosophila E-Cadherin (DE-Cad) and the apical cue Bazooka (Baz) as cells first form. Mutant analyses revealed that apical Baz accumulations can be established in the absence of AJs, whereas assembly of apical DE-Cad complexes requires Baz. Thus, Baz acts upstream of AJs during epithelial polarity establishment. During gastrulation the absence of AJs results in widespread cell dissociation and depolarization. Some epithelial structures are retained, however. These structures maintain apical Baz, accumulate apical Crumbs, and organize polarized cytoskeletons, but display abnormal cell morphology and fail to segregate the basolateral cue Discs large from the apical domain. Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues.
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Cites
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Multiple Forces Contribute to Cell Sheet Morphogenesis for Dorsal Closure in Drosophila
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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
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Cited by
Adherens junctions: from molecules to morphogenesis
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Jeanes, A., Gottardi, C. J., & Yap, A. S. (2008) · Oncogene · doi:10.1038/onc.2008.343 · Cited by 772
Tight Junctions and Cell Polarity
Shin, K., Fogg, V. C., & Margolis, B. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104219 · Cited by 745
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
Lecuit, T., Lenne, P.-F., & Munro, E. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104027 · Cited by 621
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Metadata
- Authors
- Harris, T. J. C., & Peifer, M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-10-11
- Volume
- 167
- Issue
- 1
- Pages
- 135-147
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1968981755
- Cited by
- 277
- References
- 36
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- green
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