The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Tight Junctions and Cell Polarity
Abstract
The tight junction is an intracellular junctional structure that mediates adhesion between epithelial cells and is required for epithelial cell function. Tight junctions control paracellular permeability across epithelial cell sheets and also serve as a barrier to intramembrane diffusion of components between a cell's apical and basolateral membrane domains. Recent genetic and biochemical studies in invertebrates and vertebrates indicate that tight junction proteins play an important role in the establishment and maintenance of apico-basal polarity. Proteins involved in epithelial cell polarization form evolutionarily conserved multiprotein complexes at the tight junction, and these protein complexes regulate the architecture of epithelia throughout the polarization process. Accumulating information regarding the regulation of these polarity proteins will lead to a better understanding of the molecular mechanisms whereby cell polarity is established.
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Cites
Occludin: a novel integral membrane protein localizing at tight junctions.
Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580
Multifunctional strands in tight junctions
Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067088 · Cited by 2,509
Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,095
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195
Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151
Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg 2+ Resorption
Simon, D. B., Lu, Y., Choate, K. A., Velazquez, H., Al-Sabban, E., Praga, M., Casari, G., Bettinelli, A., Colussi, G., Rodriguez-Soriano, J., et al. (1999) · Science · doi:10.1126/science.285.5424.103 · Cited by 1,147
Furuse, M., Sasaki, H., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.391 · Cited by 965
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 2×
“F or p er so na l u se o nl y. Baz: Bazooka with the active form of Cdc42, a Rho GTPase, via its semi-Cdc42/Rac interacting binding (CRIB) domain, and with part of the PDZ domain ( Joberty et al. 2000, Johansson et al. 2000, Lin et al. 2000, Qiu et al. 2000).”
BackgroundBalda, M. S., Whitney, J. A., Flores, C., González, S., Cereijido, M., & Matter, K. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.4.1031 · Cited by 875
Cited by
Wang, H.-B., Wang, P.-Y., Wang, X., Wan, Y.-L., & Liu, Y.-C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2259-4 · Cited by 827
From cells to organs: building polarized tissue
Bryant, D. M., & Mostov, K. E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2523 · Cited by 786
Tight junctions/adherens junctions: basic structure and function
Niessen, C. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700865 · Cited by 756
Epithelial Stem Cells: Turning over New Leaves
Blanpain, C., Horsley, V., & Fuchs, E. (2007) · Cell · doi:10.1016/j.cell.2007.01.014 · Cited by 594
Coordinated protein sorting, targeting and distribution in polarized cells
Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2525 · Cited by 521
Metadata
- Authors
- Shin, K., Fogg, V. C., & Margolis, B.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2006-11-01
- Volume
- 22
- Issue
- 1
- Pages
- 207-235
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2105535336
- Cited by
- 745
- References
- 170
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shin, K., Fogg, V. C., & Margolis, B. (2006). Tight Junctions and Cell Polarity. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.22.010305.104219
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
