Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

Yuneva, Mariia, Zamboni, Nicola, Oefner, Peter, Sachidanandam, Ravi, Lazebnik, Yuri·2007·The Journal of Cell Biology

DOI 10.1083/jcb.200703099

Cited by (694)

Items 101–200 of 694

Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
Ralph J. DeBerardinis · 2008 · Genetics in Medicine
Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis
Patrick A. Carroll, Daniel Diolaiti, Lisa G. McFerrin, Haiwei Gu, Danijel Djukovic, Jianhai Du, Pei Feng Cheng, Sarah Anderson, Michelle L. Ulrich, James B. Hurley et al. · 2015 · Cancer Cell
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
Nicholas Alexander Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Xiaoming Zhu, Igor Vivanco, Michael A. Teitell, Hong Wu, Antoni Ribas, Roger S. Lo et al. · 2012 · Molecular Systems Biology
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment
Dey, Prasenjit, Li, Jun, Zhang, Jianhua, Chaurasiya, Surendra, Strom, Anders, Wang, Huamin, Liao, Wen-Ting, Cavallaro, Frederick, Denz, Parker, Bernard, Vincent et al. · 2020 · Cancer Discovery
Control of glutamine metabolism by the tumor suppressor Rb
Reynolds, M R, Lane, A N, Robertson, B, Kemp, S, Liu, Y, Hill, B G, Dean, D C, Clem, B F · 2014 · Oncogene
Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection
Yongjun Yu, Amy J. Clippinger, James C. Alwine · 2011 · Trends in Microbiology
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
Vernieri, Claudio, Casola, Stefano, Foiani, Marco, Pietrantonio, Filippo, de Braud, Filippo, Longo, Valter · 2016 · Cancer Discovery
Sugar-free approaches to cancer cell killing
Nadia El Mjiyad, Alfredo Caro‐Maldonado, Silvia Ramírez‐Peinado, Cristina Muñoz‐Pinedo · 2010 · Oncogene
The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues
Goetzman, Eric S., Prochownik, Edward V. · 2018 · Frontiers in Endocrinology
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
Julian Świerczyński · 2014 · World Journal of Gastroenterology
Relevance and use of capillary coatings in capillary electrophoresis–mass spectrometry
Carolin Hühn, Rawi Ramautar, Manfred Wuhrer, Govert W. Somsen · 2009 · Analytical and Bioanalytical Chemistry
Metabolic Plasticity in Chemotherapy Resistance
María Andrea Desbats, Isabella Giacomini, Tommaso Prayer‐Galetti, Monica Montopoli · 2020 · Frontiers in Oncology
Cancer Metabolism and the Evasion of Apoptotic Cell Death
Aditi Sharma, Lawrence Boise, Mala Shanmugam · 2019 · Cancers
Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies
Zhefang Wang, Fanyu Liu, Ningbo Fan, Chenghui Zhou, Dai Li, Thomas MacVicar, Qiongzhu Dong, Christiane J. Bruns, Yue Zhao · 2020 · Frontiers in Oncology
The metabolic life and times of a T‐cell
Michalek, Ryan D., Rathmell, Jeffrey C. · 2010 · Immunological Reviews
Adipocytes Cause Leukemia Cell Resistance to L -Asparaginase via Release of Glutamine
Ehsan A. Ehsanipour, Xia Sheng, James W. Behan, Xingchao Wang, Anna M. Butturini, Vassilios I. Avramis, Steven D. Mittelman · 2013 · Cancer Research
Drug-induced amino acid deprivation as strategy for cancer therapy
Marcus Kwong Lam Fung, Gcf Chan · 2017 · Journal of Hematology & Oncology
Therapeutic targeting of cancer cell metabolism
Chi Van Dang, Max C. Hamaker, Peng Sun, Anne Le, Ping Gao · 2011 · Journal of Molecular Medicine
Exploiting the bad eating habits of Ras-driven cancers
Eileen White · 2013 · Genes & Development
Impact of MYC in regulation of tumor cell metabolism
Therese Wahlström, Marie Arsenian‐Henriksson · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells
Bradley Smith, Xenia Schafer, Aslihan Ambeskovic, Cody M. Spencer, Hartmut Land, Joshua C. Munger · 2016 · Cell Reports
Glutamine: pleiotropic roles in tumor growth and stress resistance
Shanware, Naval P., Mullen, Andrew R., DeBerardinis, Ralph J., Abraham, Robert T. · 2011 · Journal of Molecular Medicine
Autophagy and cancer cell metabolism
Fred Lozy, Vassiliki Karantza · 2012 · Seminars in Cell and Developmental Biology
Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition
Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua C. Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann et al. · 2017 · PLoS ONE
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells
Ying‐Hui Ko, Zhao Lin, Neal Flomenberg, Richard G. Pestell, Anthony Howell, Federica Sotgia, Michael P. Lisanti, Ubaldo Martinez‐Outschoorn · 2011 · Cancer Biology & Therapy
Metabolic rewiring in melanoma
Boris I. Ratnikov, David A. Scott, Andrei L. Osterman, Jeffrey W. Smith, Ze’ev A. Ronai · 2016 · Oncogene
Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
Hongkai Ji, George Y. Wu, Xiangcan Zhan, Alexandra Nolan, Cheryl M. Koh, Angelo De Marzo, Hoang Mai Doan, Jinshui Fan, Christopher Cheadle, Mohammad Fallahi et al. · 2011 · PLoS ONE
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
Lee, Shen-Han, Golinska, Monika, Griffiths, John R. · 2021 · Cells
Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
Stephen John Ralph, Sara Rodríguez‐Enríquez, Jiřı́ Neužil, Rafael Moreno‐Sánchez · 2009 · Molecular Aspects of Medicine
Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity
Mohan Rao Kaadige, Ryan Looper, Sadhaasivam Kamalanaadhan, Donald E. Ayer · 2009 · Proceedings of the National Academy of Sciences
O-GlcNAc in cancer biology
Zhiyuan Ma, Keith Vosseller · 2013 · Amino Acids
A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation
Lea Bollhalder, Alena M. Pfeil, Yuki Tomonaga, Matthias M. Schwenkglenks · 2012 · Clinical Nutrition
Mitochondrial Metabolism and Cancer
Frank D. Weinberg, Navdeep S. Chandel · 2009 · Annals of the New York Academy of Sciences
Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts
Gaglio, Daniela, Soldati, Chiara, Vanoni, Marco, Alberghina, Lilia, Chiaradonna, Ferdinando · 2009 · PLoS ONE
Glutamine homeostasis and mitochondrial dynamics
José Manuel Matés, Juan A. Segura, José Angel Campos-Sandoval, Carolina Lobo, Lorenzo Alonso, Francisco José Alonso, Javier Márquez · 2009 · The International Journal of Biochemistry & Cell Biology
Drugging the addict: non‐oncogene addiction as a target for cancer therapy
Remco Nagel, Ekaterina A Semenova, Anton J. M. Berns · 2016 · EMBO Reports
PGC-1α supports glutamine metabolism in breast cancer
Shawn McGuirk, Simon‐Pierre Gravel, Geneviève Deblois, David J. Papadopoli, Brandon Faubert, André Wegner, Karsten Hiller, Daina Zofija Avizonis, Uri David Akavia, Russell G. Jones et al. · 2013 · Cancer & Metabolism
Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer
Siwei Wei, Lingyan Liu, Jian Zhang, Jeremiah Bowers, G. A. Nagana Gowda, Harald Seeger, Tanja Natascha Fehm, Hans J. Neubauer, Ulrich Felix Vogel, Susan E. Clare et al. · 2012 · Molecular Oncology
Rational Cell Culture Optimization Enhances Experimental Reproducibility in Cancer Cells
Wright Muelas, Marina, Ortega, Fernando, Breitling, Rainer, Bendtsen, Claus, Westerhoff, Hans V. · 2018 · Scientific Reports
Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication
Minjong Lee · 2015 · World Journal of Biological Chemistry
ATF4 and N‐Myc coordinate glutamine metabolism in MYCN ‐amplified neuroblastoma cells through ASCT2 activation
Ping Ren, Ming Yue, Daibiao Xiao, Ruijuan Xiu, Lei Gan, Hudan Liu, Guoliang Qing · 2014 · The Journal of Pathology
Glutamate signalling in roots
Brian Forde · 2013 · Journal of Experimental Botany
Therapeutic Strategies Impacting Cancer Cell Glutamine Metabolism
Michael J. Lukey, Kristin F. Wilson, Richard A. Cerione · 2013 · Future Medicinal Chemistry
Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth
Omran Abu Aboud, Ching‐Hsien Chen, William T. Senapedis, Erkan Baloglu, Christian E. Argueta, Robert H. Weiss · 2016 · Molecular Cancer Therapeutics
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Edward V. Prochownik, Huabo Wang · 2021 · Cells
Redox control of glutamine utilization in cancer
Lilia Alberghina, Daniela Gaglio · 2014 · Cell Death and Disease
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
Abigail Raffner Basson, Ashley Trotter, Alexander Rodriguez‐Palacios, Fabio Cominelli · 2016 · Frontiers in Immunology
Metabolism and Brain Cancer
Suely Kazue Nagahashi Marie, Sueli Mieko Oba‐Shinjo · 2011 · Clinics
Hopefully devoted to Q: targeting glutamine addiction in cancer
E. R. Still, Mariia O. Yuneva · 2017 · British Journal of Cancer
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells
Vlad Constantin Sandulache, Thomas Julian Ow, Curtis R. Pickering, Mitchell J. Frederick, Ge Zhou, Izabela Fokt, Melinda Davis‐Malesevich, Waldemar Priebe, Jeffrey N. Myers · 2011 · Cancer
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
Anni I. Nieminen, Vilja Eskelinen, Heidi M. Haikala, Topi Aulis Tervonen, Yan Yan, Johanna I. Partanen, Juha T. Klefström · 2013 · Proceedings of the National Academy of Sciences
Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions
Radha Krishna Rao · 2012 · Journal of Epithelial Biology & Pharmacology
Amino acids in the regulation of aging and aging-related diseases
Clare-Anne Edwards Canfield, Patrick C. Bradshaw · 2019 · Translational Medicine of Aging
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
Durán, R V, MacKenzie, E D, Boulahbel, H, Frezza, C, Heiserich, L, Tardito, S, Bussolati, O, Rocha, S, Hall, M N, Gottlieb, E · 2013 · Oncogene
Altered Signaling Pathways in Prostate Cancer Drive Metabolic Fate
Antico Arciuch, Valeria Gabriela, Gueron, Geraldine, Cotignola, Javier Hernan, Vazquez, Elba Susana · 2017 · CONICET Digital (CONICET)
The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease
Naval P. Shanware, Kevin Bray, Robert T. Abraham · 2011 · The Annual Review of Pharmacology and Toxicology
Energy Metabolism Characterization of a Novel Cancer Stem Cell‐ L ike Line 3 AB ‐ OS
Roberta Palorini, Giuseppina Votta, Chiara Balestrieri, Andrea Monestiroli, Sandro Olivieri, Renza Vento, Ferdinando Chiaradonna · 2013 · Journal of Cellular Biochemistry
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Hamoud Al‐Khallaf · 2017 · Cell & Bioscience
Alternative fuels for cancer cells
Keenan, Melissa M., Chi, Jen-Tsan · 2015 · The Cancer Journal
Metabolic vulnerability of cisplatin‐resistant cancers
Florine Obrist, Judith Michels, Sylvère Durand, Alexis Chery, Jonathan G. Pol, Sarah Lévesque, Adrien Joseph, Valentina Astesana, Federico Pietrocola, Gen Sheng Wu et al. · 2018 · The EMBO Journal
Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention
Zhang, Yi, Yang, Jin-Ming · 2013 · Cancer Biology & Therapy
Role of hypoxia in the tumor microenvironment and targeted therapy
Gaoqi Chen, Kaiwen Wu, Hao Li, Demeng Xia, Tianlin He · 2022 · Frontiers in Oncology
A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle
Bolin Wang, J. Pei, Sheng-Nan Xu, Jie Liu, Jin-Ming Yu · 2024 · Journal of experimental & clinical cancer research : CR
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis
Daniel Diolaiti, Lisa G. McFerrin, Patrick A. Carroll, Robert N. Eisenman · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Reviving Lonidamine and 6-Diazo-5-oxo-L-norleucine to Be Used in Combination for Metabolic Cancer Therapy
Diana Cervantes-Madrid, Yair Romero, Alfonso Dueñas‐González · 2015 · BioMed Research International
SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma
Jeong, Seung Min, Lee, Annie, Lee, Jaewon, Haigis, Marcia C. · 2014 · Journal of Biological Chemistry
The significant role of amino acid metabolic reprogramming in cancer
Xiaohong Liu, Bo Ren, Jie Ren, Minzhi Gu, Lei You, Yu-pei Zhao · 2024 · Cell Communication and Signaling
Targeting cancer cell metabolism in pancreatic adenocarcinoma
Romain Cohen, Cindy Neuzillet, Annemilaï Tijeras‐Raballand, Sandrine J. Faivre, Armand D.E. Gramont, Éric Raymond · 2015 · Oncotarget
Role of Glutamine in Cancer: Therapeutic and Imaging Implications: FIGURE 1.
Kartik N. Rajagopalan, Ralph J. DeBerardinis · 2011 · Journal of Nuclear Medicine
Akt and c-Myc Differentially Activate Cellular Metabolic Programs and Prime Cells to Bioenergetic Inhibition
Yongjun Fan, Kathleen G. Dickman, Wei‐Xing Zong · 2009 · Journal of Biological Chemistry
The Warburg Effect Explained: Integration of Enhanced Glycolysis with Heterogeneous Mitochondria to Promote Cancer Cell Proliferation
Lilia Alberghina · 2023 · International Journal of Molecular Sciences
Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions
Xi Jin Xu, Ying Meng, Lei Li, Pengfei Xu, Jubo Wang, Zhiyu Li, Jinlei Bian · 2018 · Journal of Medicinal Chemistry
The Pleiotropic Effects of Glutamine Metabolism in Cancer
Alex J. Bott, Sara Maimouni, Wei‐Xing Zong · 2019 · Cancers
Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway
Lingqin Yuan, Xiugui Sheng, Adam K. Willson, Dario R. Roque, J.E. Stine, Hui Guo, Hannah M. Jones, Chunxiao Zhou, Victoria Lin Bae-Jump · 2015 · Endocrine Related Cancer
The Multifaceted Regulation of Mitochondria in Ferroptosis
Hao Wu, Fengli Wang, Na Ta, Ting Zhang, Weihua Gao · 2021 · Life
Amino acid management in cancer
Zhi-Yang Tsun, Richard Possemato · 2015 · Seminars in Cell and Developmental Biology
Control of mammalian gene expression by amino acids, especially glutamine
Carole Brasse‐Lagnel, Alain Lavoinne, Annie Husson · 2009 · FEBS Journal
Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer
Bo Li, Marie Celeste Simon · 2013 · Clinical Cancer Research
Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells
Lukas Badertscher, Thomas Wild, Christian Montellese, Leila T. Alexander, Lukas Bammert, Marie Sárazová, Michael Stebler, Gábor Csúcs, Thomas U. Mayer, Nicola Zamboni et al. · 2015 · Cell Reports
Altered Glutamine Metabolism and Therapeutic Opportunities for Lung Cancer
Amr Mohamed, Xingming Deng, Fadlo Raja Khuri, Taofeek Kunle Owonikoko · 2013 · Clinical Lung Cancer
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival
Erica L. Sanchez, Patrick A. Carroll, Angel B. Thalhofer, Michael Lagunoff · 2015 · PLoS Pathogens
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
Katarína Smolková, Petr Ježek · 2012 · International Journal of Cell Biology
Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose
Hiroaki Okuyama, Hiroko Endo, Tamaki Akashika, Kikuya Kato, Masahiro Inoue · 2010 · Cancer Research
Glutamine Addiction In Gliomas
Javier Márquez, Francisco José Alonso, José Manuel Matés, Juan A. Segura, Mercedes Martín‐Rufián, José Angel Campos-Sandoval · 2017 · Neurochemical Research
Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
Jade Mims, Nidhi Bansal, Manish S. Bharadwaj, Xiaofei Chen, Anthony J. A. Molina, Allen W. Tsang, Cristina M. Furdui · 2015 · Radiation Research
Stress-induced cleavage of Myc promotes cancer cell survival
Maralice Conacci‐Sorrell, Celine Ngouenet, Sarah Anderson, Thomas Brabletz, Robert N. Eisenman · 2014 · Genes & Development
Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism
Chi Van Dang · 2011 · Cold Spring Harbor Symposia on Quantitative Biology
Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism
Jae Hyun Kim, Kyoung Jin Lee, Yoojeong Seo, Ji-Hee Kwon, Jae Pil Yoon, Jo Yeon Kang, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon et al. · 2018 · Scientific Reports
LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation
Ruijie Wang, Leixi Cao, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Fengmin Shao, Lirong Zhang, Mian Wu · 2021 · Science Advances
[18F](2 S ,4 R )4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition
Rong Zhou, Austin R. Pantel, Shihong Li, Brian P. Lieberman, Karl Plöessl, Hoon Choi, Eric R. Blankemeyer, Hsiaoju S. Lee, Hank F. Kung, Robert H. Mach et al. · 2017 · Cancer Research
Inhibition of Lactate Dehydrogenase Activity as an Approach to Cancer Therapy
LUIGI FIUME, Marcella Manerba, Marina Vettraino, Giuseppina Di Stefano · 2014 · Future Medicinal Chemistry
Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells
Chih‐Sheng Yang, Eleni Stampouloglou, Nathan M. Kingston, Liye Zhang, Stefano Monti, Xaralabos Varelas · 2018 · EMBO Reports
Altered glutamine metabolism in platinum resistant ovarian cancer
Chantelle D. Hudson, Alyssa Savadelis, Anil Belur Nagaraj, Peronne L. Joseph, Stefanie Avril, Analisa V. DiFeo, Norbert E. Avril · 2016 · Oncotarget
2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma
Silvia Ramírez‐Peinado, Fermín Alcázar-Limones, Laura Lagares‐Tena · 2011 · Cancer Research
Clinical significance of T cell metabolic reprogramming in cancer
Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver, Vassiliki A. Boussiotis · 2016 · Clinical and Translational Medicine
Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth
Meng Yuan, Bo Tu, Hengchao Li, Huanhuan Pang, Nan Zhang, Minghe Fan, Jingru Bai, Wei Wang, Zhaoqi Shu, Christopher C. DuFort et al. · 2022 · Nature Cancer
Regulation of rDNA transcription in response to growth factors, nutrients and energy
Eric P. Kusnadi, Katherine M. Hannan, Rodney J. Hicks, Ross D. Hannan, Richard B. Pearson, Jian Kang · 2014 · Gene
Long Noncoding RNA GCASPC , a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase–Dependent Cell Proliferation in Gallbladder Cancer
Mingzhe Ma, Yan Zhang, Mingzhe Weng, Shou-hua Wang, Ye Hu, Zhaoyuan Hou, Yiyu Qin, Wei Gong, Yongjie Zhang, Xiang Kong et al. · 2016 · Cancer Research
Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells
Taylor A. Murphy, Chi Van Dang, Jamey D. Young · 2012 · Metabolic Engineering
Metabolic reprogramming in tumors: Contributions of the tumor microenvironment
Lane, Andrew N., Higashi, Richard M., Fan, Teresa W-M. · 2020 · Genes & Diseases