Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention
Open accessAbstract
The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.
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Glycolytic intermediates serve as precursors for macromolecular biosynthesis, support tumor invasion and metastasis, and contribute to the development of drug resistance.
“Beyond energy production, glycolytic intermediates serve as precursors for macromolecular biosynthesis, support tumor invasion and metastasis, and contribute to the development of drug resistance (12).”
From Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma (2026) · cites this paper as [12]
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- Authors
- Zhang, Y., & Yang, J.-M.
- Affiliations
- Soochow University (CN)
- ORCID
- Zhang, Yi
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2013-02
- Volume
- 14
- Issue
- 2
- Pages
- 81-89
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- PMC
- PMC3572003
- OpenAlex
- W1991730422
- Cited by
- 132
- References
- 72
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 13 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 20 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 13 · 2014: 3 · 2013: 4
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Biology & Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions (81072146, R01CA135038)
- National Cancer Institute (R01CA135038)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cancer metabolism, Warburg effect, glycolysis, mitochondrial metabolism, glutamine metabolism, metabolic reprogramming, tumor growth, metabolic targeting, cancer therapy
- MeSH terms
- Antineoplastic Agents, Energy Metabolism, Glutamine, Glycolysis, Humans, Mitochondria, Neoplasms, Oxidative Phosphorylation, Metabolic Networks and Pathways
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