Cited by 132Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention

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Zhang, Yi, Yang, Jin-Ming·2013·Cancer Biology & Therapy

Abstract

The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

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Crossref · 10.4161/cbt.22958

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Authors
Zhang, Y., & Yang, J.-M.
Affiliations
Soochow University (CN)
Venue
Cancer Biology & Therapy
Published
2013-02
Volume
14
Issue
2
Pages
81-89
ISSN
  • 1538-4047 (ISSN-L)
  • 1555-8576
OpenAlex
W1991730422
Cited by
132
References
72
Citations by year
2026: 3 · 2025: 6 · 2024: 13 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 20 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 13 · 2014: 3 · 2013: 4
FWCI
0.77
Type
journal article
Language
en
Open access
Locations
  • Cancer Biology & Therapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Priority Academic Program Development of Jiangsu Higher Education Institutions (81072146, R01CA135038)
  • National Cancer Institute (R01CA135038)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
cancer metabolism, Warburg effect, glycolysis, mitochondrial metabolism, glutamine metabolism, metabolic reprogramming, tumor growth, metabolic targeting, cancer therapy
MeSH terms
Antineoplastic Agents, Energy Metabolism, Glutamine, Glycolysis, Humans, Mitochondria, Neoplasms, Oxidative Phosphorylation, Metabolic Networks and Pathways

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