The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium
Open accessAbstract
The HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells. Sox9 expression requires an active β-catenin–Tcf complex, the transcriptional effector of the Wnt pathway. This pathway is critical for numerous aspects of the intestinal epithelium physiopathology, but processes that specify the cell response to such multipotential signals still remain to be identified. We inactivated the Sox9 gene in the intestinal epithelium to analyze its physiological function. Sox9 inactivation affected differentiation throughout the intestinal epithelium, with a disappearance of Paneth cells and a decrease of the goblet cell lineage. Additionally, the morphology of the colon epithelium was severely altered. We detected general hyperplasia and local crypt dysplasia in the intestine, and Wnt pathway target genes were up-regulated. These results highlight the central position of Sox9 as both a transcriptional target and a regulator of the Wnt pathway in the regulation of intestinal epithelium homeostasis.
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Cites
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Cited by
Comprehensive molecular characterization of human colon and rectal cancer
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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
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Metadata
- Authors
- Bastide, P., Darido, C., Pannequin, J., Kist, R., Robine, S., Marty-Double, C., Bibeau, F., Scherer, G., Joubert, D., Hollande, F., Blache, P., & Jay, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-08-13
- Volume
- 178
- Issue
- 4
- Pages
- 635-648
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2152501601
- Cited by
- 494
- References
- 40
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Bastide, P., Darido, C., Pannequin, J., Kist, R., Robine, S., Marty-Double, C., Bibeau, F., Scherer, G., Joubert, D., Hollande, F., Blache, P., & Jay, P. (2007). Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200704152
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