The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense
Abstract
Precursors of α-defensin peptides require activation for bactericidal activity. In mouse small intestine, matrilysin colocalized with α-defensins (cryptdins) in Paneth cell granules, and in vitro it cleaved the pro segment from cryptdin precursors. Matrilysin-deficient (MAT −/− ) mice lacked mature cryptdins and accumulated precursor molecules. Intestinal peptide preparations from MAT −/− mice had decreased antimicrobial activity. Orally administered bacteria survived in greater numbers and were more virulent in MAT −/− mice than in MAT +/+ mice. Thus, matrilysin functions in intestinal mucosal defense by regulating the activity of defensins, which may be a common role for this metalloproteinase in its numerous epithelial sites of expression.
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Citations
Cites
Pilus and nonpilus bacterial adhesins: Assembly and function in cell recognition
Hultgren, S. J., Abraham, S., Caparon, M., Falk, P., Geme, J. W. S., & Normark, S. (1993) · Cell · doi:10.1016/0092-8674(93)90269-v · Cited by 409
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Cited by
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575
How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Matrix metalloproteinases and the regulation of tissue remodelling
Page-McCaw, A., Ewald, A. J., & Werb, Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2125 · Cited by 2,630
Metadata
- Authors
- Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C.
- Venue
- Science
- Published
- 1999-10
- Volume
- 286
- Issue
- 5437
- Pages
- 113-117
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1991625690
- Cited by
- 1,074
- References
- 1
- FWCI
- 27.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999). Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense. Science. https://doi.org/10.1126/science.286.5437.113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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