The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Structural basis of filamin A functions
Open accessAbstract
Filamin A (FLNa) can effect orthogonal branching of F-actin and bind many cellular constituents. FLNa dimeric subunits have N-terminal spectrin family F-actin binding domains (ABDs) and an elongated flexible segment of 24 immunoglobulin (Ig) repeats. We generated a library of FLNa fragments to examine their F-actin binding to define the structural properties of FLNa that enable its various functions. We find that Ig repeats 9–15 contain an F-actin–binding domain necessary for high avidity F-actin binding. Ig repeats 16–24, where most FLNa-binding partners interact, do not bind F-actin, and thus F-actin does not compete with Ig repeat 23 ligand, FilGAP. Ig repeats 16–24 have a compact structure that suggests their unfolding may accommodate pre-stress–mediated stiffening of F-actin networks, partner binding, mechanosensing, and mechanoprotection properties of FLNa. Our results also establish the orientation of FLNa dimers in F-actin branching. Dimerization, mediated by FLNa Ig repeat 24, accounts for rigid high-angle FLNa/F-actin branching resistant to bending by thermal forces, and high avidity F-actin binding and cross-linking.
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Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Filamins as integrators of cell mechanics and signalling
Stossel, T. P., Condeelis, J., Cooley, L., Hartwig, J. H., Noegel, A., Schleicher, M., & Shapiro, S. S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052082 · Cited by 1,020
Self-citationHuman endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.
Gorlin, J. B., Yamin, R., Egan, S., Stewart, M., Stossel, T. P., Kwiatkowski, D. J., & Hartwig, J. H. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.3.1089 · Cited by 519
Self-citationThe many faces of filamin: A versatile molecular scaffold for cell motility and signalling
Feng, Y., & Walsh, C. A. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1034 · Cited by 503
The Molecular Basis of Filamin Binding to Integrins and Competition with Talin
Kiema, T., Lad, Y., Jiang, P., Oxley, C. L., Baldassarre, M., Wegener, K. L., Campbell, I. D., Ylänne, J., & Calderwood, D. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.011 · Cited by 434
The OPD-spectrum Disorders Clinical Collaborative Group, Robertson, S. P., Twigg, S. R. F., Sutherland-Smith, A. J., Biancalana, V., Gorlin, R. J., Horn, D., Kenwrick, S. J., Kim, C. A., Morava, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1119 · Cited by 430
Gardel, M. L., Nakamura, F., Hartwig, J. H., Crocker, J. C., Stossel, T. P., & Weitz, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504777103 · Cited by 412
Self-citationFilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
Ohta, Y., Hartwig, J. H., & Stossel, T. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1437 · Cited by 389
Self-citationWinder, S. J., & Ayscough, K. R. (2005) · Journal of Cell Science · doi:10.1242/jcs.01670 · Cited by 388
Filamin A (FLNA) is required for cell–cell contact in vascular development and cardiac morphogenesis
Feng, Y., Chen, M. H., Moskowitz, I. P., Mendonza, A. M., Vidali, L., Nakamura, F., Kwiatkowski, D. J., & Walsh, C. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609628104 · Cited by 323
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Cited by
The filamins: Organizers of cell structure and function
Nakamura, F., Stossel, T. P., & Hartwig, J. H. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.2.14401 · Cited by 451
Self-citationAkilesh, S., Suleiman, H., Yu, H., Stander, M. C., Lavin, P., Gbadegesin, R., Antignac, C., Pollak, M., Kopp, J. B., Winn, M. P., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46458 · Cited by 277
Bieling, P., Li, T.-D., Weichsel, J., McGorty, R., Jreij, P., Huang, B., Fletcher, D. A., & Mullins, R. D. (2016) · Cell · doi:10.1016/j.cell.2015.11.057 · Cited by 263
Computational screening of filamin mechanical binding proteins using AlphaFold2
(2025) · doi:10.1139/bcb-2025-0194 · Cited by 3
Metadata
- Authors
- Nakamura, F., Osborn, T. M., Hartemink, C. A., Hartwig, J. H., & Stossel, T. P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-12-03
- Volume
- 179
- Issue
- 5
- Pages
- 1011-1025
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2064818197
- Cited by
- 271
- References
- 38
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- green
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