The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3
Open accessAbstract
Vascular sprouting is a key process-driving development of the vascular system. In this study, we show that neuropilin-2 (Nrp2), a transmembrane receptor for the lymphangiogenic vascular endothelial growth factor C (VEGF-C), plays an important role in lymphatic vessel sprouting. Blocking VEGF-C binding to Nrp2 using antibodies specifically inhibits sprouting of developing lymphatic endothelial tip cells in vivo. In vitro analyses show that Nrp2 modulates lymphatic endothelial tip cell extension and prevents tip cell stalling and retraction during vascular sprout formation. Genetic deletion of Nrp2 reproduces the sprouting defects seen after antibody treatment. To investigate whether this defect depends on Nrp2 interaction with VEGF receptor 2 (VEGFR2) and/or 3, we intercrossed heterozygous mice lacking one allele of these receptors. Double-heterozygous nrp2vegfr2 mice develop normally without detectable lymphatic sprouting defects. In contrast, double-heterozygote nrp2vegfr3 mice show a reduction of lymphatic vessel sprouting and decreased lymph vessel branching in adult organs. Thus, interaction between Nrp2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C.
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Cites
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
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Self-citationLymphangiogenesis in development and human disease
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Self-citationHyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
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Self-citationFunctionally specialized junctions between endothelial cells of lymphatic vessels
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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
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Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
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Self-citationBlocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
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Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13145 · Cited by 2,155
Vascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Identification and functional analysis of endothelial tip cell–enriched genes
del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J. S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., et al. (2010) · Blood · doi:10.1182/blood-2010-02-270819 · Cited by 474
Self-citationSabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411
Lymphatic Vessel Network Structure and Physiology
Breslin, J. W., Yang, Y., Scallan, J. P., Sweat, R. S., Adderley, S. P., & Murfee, W. L. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c180015 · Cited by 341
Metadata
- Authors
- Xu, Y., Yuan, L., Mak, J., Pardanaud, L., Caunt, M., Kasman, I., Larrivée, B., del Toro, R., Suchting, S., Medvinsky, A., Silva, J., Yang, J., Thomas, J.-L., Koch, A. W., Alitalo, K., Eichmann, A., & Bagri, A.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-01-11
- Volume
- 188
- Issue
- 1
- Pages
- 115-130
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2108574077
- Cited by
- 339
- References
- 52
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xu, Y., Yuan, L., Mak, J., Pardanaud, L., Caunt, M., Kasman, I., Larrivée, B., del Toro, R., Suchting, S., Medvinsky, A., Silva, J., Yang, J., Thomas, J.-L., Koch, A. W., Alitalo, K., Eichmann, A., & Bagri, A. (2010). Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3. Journal of Cell Biology. https://doi.org/10.1083/jcb.200903137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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