The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Force transmission in migrating cells
Open accessAbstract
During cell migration, forces generated by the actin cytoskeleton are transmitted through adhesion complexes to the substrate. To investigate the mechanism of force generation and transmission, we analyzed the relationship between actin network velocity and traction forces at the substrate in a model system of persistently migrating fish epidermal keratocytes. Front and lateral sides of the cell exhibited much stronger coupling between actin motion and traction forces than the trailing cell body. Further analysis of the traction–velocity relationship suggested that the force transmission mechanisms were different in different cell regions: at the front, traction was generated by a gripping of the actin network to the substrate, whereas at the sides and back, it was produced by the network’s slipping over the substrate. Treatment with inhibitors of the actin–myosin system demonstrated that the cell body translocation could be powered by either of the two different processes, actomyosin contraction or actin assembly, with the former associated with significantly larger traction forces than the latter.
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Cites
Rapid leukocyte migration by integrin-independent flowing and squeezing
Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397
Cited by
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Trepat, X., Chen, Z., & Jacobson, K. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110012 · Cited by 406
Traction force microscopy in physics and biology
Style, R. W., Boltyanskiy, R., German, G. K., Hyland, C., MacMinn, C. W., Mertz, A. F., Wilen, L. A., Xu, Y., & Dufresne, E. R. (2014) · Soft Matter · doi:10.1039/c4sm00264d · Cited by 349
Schwarz, U. S., & Gardel, M. L. (2012) · Journal of Cell Science · doi:10.1242/jcs.093716 · Cited by 339
An Adhesion-Dependent Switch between Mechanisms That Determine Motile Cell Shape
Barnhart, E. L., Lee, K.-C., Keren, K., Mogilner, A., & Theriot, J. A. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001059 · Cited by 310
Metadata
- Authors
- Fournier, M. F., Sauser, R., Ambrosi, D., Meister, J.-J., & Verkhovsky, A. B.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-01-25
- Volume
- 188
- Issue
- 2
- Pages
- 287-297
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2107750328
- Cited by
- 231
- References
- 1
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fournier, M. F., Sauser, R., Ambrosi, D., Meister, J.-J., & Verkhovsky, A. B. (2010). Force transmission in migrating cells. Journal of Cell Biology. https://doi.org/10.1083/jcb.200906139
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
