The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
An Adhesion-Dependent Switch between Mechanisms That Determine Motile Cell Shape
Open accessAbstract
Keratocytes are fast-moving cells in which adhesion dynamics are tightly coupled to the actin polymerization motor that drives migration, resulting in highly coordinated cell movement. We have found that modifying the adhesive properties of the underlying substrate has a dramatic effect on keratocyte morphology. Cells crawling at intermediate adhesion strengths resembled stereotypical keratocytes, characterized by a broad, fan-shaped lamellipodium, clearly defined leading and trailing edges, and persistent rates of protrusion and retraction. Cells at low adhesion strength were small and round with highly variable protrusion and retraction rates, and cells at high adhesion strength were large and asymmetrical and, strikingly, exhibited traveling waves of protrusion. To elucidate the mechanisms by which adhesion strength determines cell behavior, we examined the organization of adhesions, myosin II, and the actin network in keratocytes migrating on substrates with different adhesion strengths. On the whole, our results are consistent with a quantitative physical model in which keratocyte shape and migratory behavior emerge from the self-organization of actin, adhesions, and myosin, and quantitative changes in either adhesion strength or myosin contraction can switch keratocytes among qualitatively distinct migration regimes.
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Citations
Cites
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Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
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RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
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BackgroundRegulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
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Soft Lithography in Biology and Biochemistry
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Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
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Focal Contacts as Mechanosensors
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Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
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Cited by
Schwarz, U. S., & Gardel, M. L. (2012) · Journal of Cell Science · doi:10.1242/jcs.093716 · Cited by 339
Raab, M., Swift, J., P. Dingal, P. C. D., Shah, P., Shin, J.-W., & Discher, D. E. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201205056 · Cited by 285
Vinculin forms a directionally asymmetric catch bond with F-actin
Huang, D. L., Bax, N. A., Buckley, C. D., Weis, W. I., & Dunn, A. R. (2017) · Science · doi:10.1126/science.aan2556 · Cited by 283
Metadata
- Authors
- Barnhart, E. L., Lee, K.-C., Keren, K., Mogilner, A., & Theriot, J. A.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-05-03
- Volume
- 9
- Issue
- 5
- Pages
- e1001059
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2047903964
- Cited by
- 310
- References
- 63
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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