The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
Open accessAbstract
Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, and proliferation. However, how Pax7 is regulated during the transition from proliferating satellite cells to differentiating myogenic progenitor cells is largely unknown. In this study, we find that miR-1 and miR-206 are sharply up-regulated during satellite cell differentiation and down-regulated after muscle injury. We show that miR-1 and miR-206 facilitate satellite cell differentiation by restricting their proliferative potential. We identify Pax7 as one of the direct regulatory targets of miR-1 and miR-206. Inhibition of miR-1 and miR-206 substantially enhances satellite cell proliferation and increases Pax7 protein level in vivo. Conversely, sustained Pax7 expression as a result of the loss of miR-1 and miR-206 repression elements at its 3′ untranslated region significantly inhibits myoblast differentiation. Therefore, our experiments suggest that microRNAs participate in a regulatory circuit that allows rapid gene program transitions from proliferation to differentiation.
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Cited by
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novak, J., & Bienertova-Vasku, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 478
miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7
Dey, B. K., Gagan, J., & Dutta, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01009-10 · Cited by 408
Metadata
- Authors
- Chen, J.-F., Tao, Y., Li, J., Deng, Z., Yan, Z., Xiao, X., & Wang, D.-Z.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-09-06
- Volume
- 190
- Issue
- 5
- Pages
- 867-879
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2114395071
- Cited by
- 592
- References
- 56
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, J.-F., Tao, Y., Li, J., Deng, Z., Yan, Z., Xiao, X., & Wang, D.-Z. (2010). microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. Journal of Cell Biology. https://doi.org/10.1083/jcb.200911036
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