Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
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Inactivation of C. elegans Dicer (dcr-1) causes heterochronic phenotypes similar to let-7 and lin-4 mutations.
“Inactivation of C. elegans Dicer (dcr-1) causes heterochronic phenotypes similar to let-7 and lin-4 mutations (Grishok et al. 2001).”
From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Grishok et al. 2001
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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- [1]1. Ambros, V. A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans Cell. 1989; 57:49-57
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“The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce a stem-loop precursor miR of approximately 70 nucleotides in length (pre-miR), which is cleaved by the cytoplasmic Dicer ribonuclease to produce two products, the mature miR and the antisense miR star (miRNA*) 5,6 .”
- Authors
- Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G., & Mello, C. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 106
- Issue
- 1
- Pages
- 23-34
- ISSN
- 0092-8674
- Cited by
- 1,600
- References
- 2
- Language
- en
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