The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
FAK promotes recruitment of talin to nascent adhesions to control cell motility
Open accessAbstract
Cell migration is a dynamic process that involves the continuous formation, maturation, and turnover of matrix–cell adhesion sites. New (nascent) adhesions form at the protruding cell edge in a tension-independent manner and are comprised of integrin receptors, signaling, and cytoskeletal-associated proteins. Integrins recruit focal adhesion kinase (FAK) and the cytoskeletal protein talin to nascent adhesions. Canonical models support a role for talin in mediating FAK localization and activation at adhesions. Here, alternatively, we show that FAK promotes talin recruitment to nascent adhesions occurring independently of talin binding to β1 integrins. The direct binding site for talin on FAK was identified, and a point mutation in FAK (E1015A) prevented talin association and talin localization to nascent adhesions but did not alter integrin-mediated FAK recruitment and activation at adhesions. Moreover, FAK E1015A inhibited cell motility and proteolytic talin cleavage needed for efficient adhesion dynamics. These results support an alternative linkage for FAK–talin interactions within nascent adhesions essential for the control of cell migration.
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Cites
Choi, C. K., Vicente-Manzanares, M., Zareno, J., Whitmore, L. A., Mogilner, A., & Horwitz, A. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1763 · Cited by 797
Calderwood, D. A., Zent, R., Grant, R., Rees, D. J. G., Hynes, R. O., & Ginsberg, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28071 · Cited by 720
Self-citationDi Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature · doi:10.1038/nature01147 · Cited by 441
Cited by
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Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3792 · Cited by 1,381
Self-citationIntegrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Targeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520
FAK signaling in human cancer as a target for therapeutics
Lee, B. Y., Timpson, P., Horvath, L. G., & Daly, R. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.10.001 · Cited by 425
Metadata
- Authors
- Lawson, C., Lim, S.-T., Uryu, S., Chen, X. L., Calderwood, D. A., & Schlaepfer, D. D.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-01-23
- Volume
- 196
- Issue
- 2
- Pages
- 223-232
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W3081487045
- Cited by
- 222
- References
- 3
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lawson, C., Lim, S.-T., Uryu, S., Chen, X. L., Calderwood, D. A., & Schlaepfer, D. D. (2012). FAK promotes recruitment of talin to nascent adhesions to control cell motility. Journal of Cell Biology. https://doi.org/10.1083/jcb.201108078
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