The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
Open accessAbstract
Although brain-derived neurotrophic factor (BDNF) regulates numerous and complex biological processes including memory retention, its extremely low levels in the mature central nervous system have greatly complicated attempts to reliably localize it. Using rigorous specificity controls, we found that antibodies reacting either with BDNF or its pro-peptide both stained large dense core vesicles in excitatory presynaptic terminals of the adult mouse hippocampus. Both moieties were ∼10-fold more abundant than pro-BDNF. The lack of postsynaptic localization was confirmed in Bassoon mutants, a seizure-prone mouse line exhibiting markedly elevated levels of BDNF. These findings challenge previous conclusions based on work with cultured neurons, which suggested activity-dependent dendritic synthesis and release of BDNF. They instead provide an ultrastructural basis for an anterograde mode of action of BDNF, contrasting with the long-established retrograde model derived from experiments with nerve growth factor in the peripheral nervous system.
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Self-citationCa2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
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Molecular cloning and expression of brain-derived neurotrophic factor
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Self-citationHippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
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Mice lacking brain-derived neurotrophic factor develop with sensory deficits
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Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.
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Cited by
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750
Axonal transport: cargo-specific mechanisms of motility and regulation
Maday, S., Twelvetrees, A. E., Moughamian, A. J., & Holzbaur, E. L. F. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.019 · Cited by 683
Metadata
- Authors
- Dieni, S., Matsumoto, T., Dekkers, M., Rauskolb, S., Ionescu, M. S., Deogracias, R., Gundelfinger, E. D., Kojima, M., Nestel, S., Frotscher, M., & Barde, Y.-A.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-03-12
- Volume
- 196
- Issue
- 6
- Pages
- 775-788
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2137572159
- Cited by
- 346
- References
- 83
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. https://app.cochat.ai/papers/10.1083/jcb.201201038
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- Dieni, S., Matsumoto, T., Dekkers, M., Rauskolb, S., Ionescu, M. S., Deogracias, R., Gundelfinger, E. D., Kojima, M., Nestel, S., Frotscher, M., & Barde, Y.-A. (2012). BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. Journal of Cell Biology. https://doi.org/10.1083/jcb.201201038
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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