Cited by 244Cellular Mechanics and InteractionsMicrotubule and mitosis dynamicsCell Adhesion Molecules Research

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Targeting and transport: How microtubules control focal adhesion dynamics

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Stehbens, Samantha, Wittmann, Torsten·2012·Journal of Cell Biology

DOI 10.1083/jcb.201206050PMC PMC3514042

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Abstract

Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge.

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Authors: Stehbens, S., & Wittmann, T.
Affiliations: University of California, San Francisco (US)
Corresponding author: Wittmann, Torsten
ORCID: Stehbens, Samantha
Wittmann, Torsten
Venue: Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 2012-08-20
Volume: 198
Issue: 4
Pages: 481-489
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.201206050
PMC: PMC3514042
OpenAlex: W2102283558
Cited by: 244
References: 111
Citations by year: 2026: 8 · 2025: 9 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 25 · 2018: 21 · 2017: 16 · 2016: 30 · 2015: 20 · 2014: 28 · 2013: 18 · 2012: 2
FWCI: 2.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Cell Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of General Medical Sciences (R01GM079139)
National Center for Research Resources (C06RR16490, C06RR016490, S10RR026758)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: microtubules, focal adhesions, cell migration, integrins, extracellular matrix, microtubule plus-end tracking proteins, Rho GTPase signaling, endocytosis, clathrin, matrix metalloproteinases, focal adhesion turnover, cell polarity
MeSH terms: Animals, Endocytosis, Extracellular Matrix, Humans, Microtubules, Signal Transduction, Focal Adhesions

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Targeting and transport: How microtubules control focal adhesion dynamics

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