Cited by 277Ferroptosis and cancer prognosisPlant Stress Responses and ToleranceCell death mechanisms and regulation

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Heat stress induces ferroptosis-like cell death in plants

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Distéfano, Ayelén Mariana, Martin, María Victoria, Córdoba, Juan Pablo, Bellido, Andrés Martín, D’Ippólito, Sebastián, Colman, Silvana Lorena, Soto, Débora, Roldán, Juan Alfredo, Bartoli, Carlos Guillermo, Zabaleta, Eduardo Julián, Fiol, Diego Fernando, Stockwell, Brent R., Dixon, Scott J., Pagnussat, Gabriela Carolina·2017·Journal of Cell Biology

DOI 10.1083/jcb.201605110PMC PMC5294777

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Abstract

In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient.

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Self-citation
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Self-citation
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Griffith, O. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90139-6 · Cited by 4,628
Heat tolerance in plants: An overview
Wahid, A., Gelani, S., Ashraf, M., & Foolad, M. R. (2007) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2007.05.011 · Cited by 4,218
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citation
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288
Ascorbate and Glutathione: The Heart of the Redox Hub
Foyer, C. H., & Noctor, G. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.167569 · Cited by 2,559
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329
Self-citation
Autophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,237

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Schneider, 1992, Reduced glutathione (GSH) transport in cultured tobacco cells, Plant Physiol. Biochem., 30, 29

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[Cerebral ischemic malacia. A retrospective study of CAT scan-documented cases].
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Additional file 2 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600708
Additional file 5 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600717
Additional file 7 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600723
Additional file 8 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600726
Additional file 6 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600720
Additional file 3 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600711
Additional file 4 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600714
Additional file 9 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses
Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600729
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Glossary
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About the Dead Man and Fungi
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Sánchez‐Sanuy, F., Mateluna-Cuadra, R., Tomita, K., Okada, K., Sacchi, G. A., Campo, S., & Segundo, B. S. (2023) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · doi:10.6084/m9.figshare.22600705
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Villa, E. (2017) · theses.fr (ABES) · doi:10.70675/f0d1579dzdd47z4ac8z82abz4e3b85a0100b
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Montacié, C. (2019) · theses.fr (ABES) · doi:10.70675/19513209z9ae3z4903z9d88z0d9e3ee4a286
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Kago-Gachao, L., Salas, C., Campos, M., Whitmore, G., & Sueldo, D. J. (2026) · BIO-PROTOCOL · doi:10.21769/bioprotoc.5650
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Authors: Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., Fiol, D. F., Stockwell, B. R., Dixon, S. J., & Pagnussat, G. C.
Affiliations: Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Columbia University (US)
Stanford University (US)
Corresponding author: Dixon, Scott J.
Pagnussat, Gabriela Carolina
ORCID: Distéfano, Ayelén Mariana
Martin, María Victoria
Córdoba, Juan Pablo
Bellido, Andrés Martín
Colman, Silvana Lorena
Roldán, Juan Alfredo
Bartoli, Carlos Guillermo
Zabaleta, Eduardo Julián
Fiol, Diego Fernando
Stockwell, Brent R.
Dixon, Scott J.
Pagnussat, Gabriela Carolina
Venue: Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 2017-01-18
Volume: 216
Issue: 2
Pages: 463-476
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.201605110
PMC: PMC5294777
OpenAlex: W2577539162
Cited by: 268
References: 73
Citations by year: 2026: 17 · 2025: 33 · 2024: 43 · 2023: 29 · 2022: 36 · 2021: 50 · 2020: 25 · 2019: 12 · 2018: 11 · 2017: 11
FWCI: 13.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.rupress.org/terms/ (vor, 988 d)
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 201 d)
Locations: The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
Americanae (AECID Library) (publishedVersion, other-oa)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Funders: Howard Hughes Medical Institute (55007430)
National Institutes of Health (5R01CA097061, R35CA209896)
National Cancer Institute (4R00CA166517-03)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: ferroptosis, heat stress, regulated cell death, plant cell death, iron-dependent cell death, glutathione depletion, vitamin C, lipid reactive oxygen species, oxidative stress, root cells, Arabidopsis thaliana
MeSH terms: Antioxidants, Ascorbic Acid, Glutathione, Hot Temperature, Iron, Iron Chelating Agents, Microscopy, Fluorescence, Oxidation-Reduction, Plant Proteins, Time Factors, Lipid Peroxidation, Signal Transduction, Cell Death, Arabidopsis, Reactive Oxygen Species, Oxidative Stress, Plant Roots, Heat-Shock Response, Evolution, Molecular

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Heat stress induces ferroptosis-like cell death in plants

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