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Heat stress induces ferroptosis-like cell death in plants
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In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient.
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“a ferroptosis-like RCD subroutine has been described in plants responding to moderate heat stress, supporting some degree of evolutionary conservation and the relevance of ferroptosis for organismal homeostasis [601].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [601]
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Metadata
- Authors
- Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., Fiol, D. F., Stockwell, B. R., Dixon, S. J., & Pagnussat, G. C.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Columbia University (US)
- Stanford University (US)
- Corresponding author
- Dixon, Scott J.
- Pagnussat, Gabriela Carolina
- ORCID
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2017-01-18
- Volume
- 216
- Issue
- 2
- Pages
- 463-476
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC5294777
- OpenAlex
- W2577539162
- Cited by
- 268
- References
- 73
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 43 · 2023: 29 · 2022: 36 · 2021: 50 · 2020: 25 · 2019: 12 · 2018: 11 · 2017: 11
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- Americanae (AECID Library) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Funders
- Howard Hughes Medical Institute (55007430)
- National Institutes of Health (5R01CA097061, R35CA209896)
- National Cancer Institute (4R00CA166517-03)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- ferroptosis, heat stress, regulated cell death, plant cell death, iron-dependent cell death, glutathione depletion, vitamin C, lipid reactive oxygen species, oxidative stress, root cells, Arabidopsis thaliana
- MeSH terms
- Antioxidants, Ascorbic Acid, Glutathione, Hot Temperature, Iron, Iron Chelating Agents, Microscopy, Fluorescence, Oxidation-Reduction, Plant Proteins, Time Factors, Lipid Peroxidation, Signal Transduction, Cell Death, Arabidopsis, Reactive Oxygen Species, Oxidative Stress, Plant Roots, Heat-Shock Response, Evolution, Molecular
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