The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors.
Open accessAbstract
The morphological effects of epidermal growth factor (EGF) on human carcinoma cells A-431 have been examined by scanning electron microscopy. These flat polygonal cells normally exhibit only small membrane folds, but show extensive ruffling and extension of filopodia within 5 min of exposure to EGF at 37 degrees C. This ruffling activity is transient, subsiding within another 5--15 min, but several other changes in surface morphology follow. Within the first hour of exposure to the hormone, the cell surface becomes exceedingly smooth and the nuclei seem to protrude above the plane of the otherwise thin monolayer, giving the cells a "fried egg" appearance. Cells at the edges of colonies gradually retract from the substrate, leading to reorganization, by 12 h, of the monolayer into multilayered colonies. EGF thus induces both rapid and long-term alterations in the morphology of these epidermoid cells.
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Citations
Cites
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Self-citationHaigler, H. T., McKanna, J. A., & Cohen, S. (1979) · The Journal of cell biology · doi:10.1083/jcb.81.2.382 · Cited by 526
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Self-citationRapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.
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Self-citation
Cited by
Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins
Bar-Sagi, D., & Feramisco, J. R. (1986) · Science · doi:10.1126/science.3090687 · Cited by 734
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor
Ek, B., Westermark, B., Wasteson, Å., & Heldin, C.-H. (1982) · Nature · doi:10.1038/295419a0 · Cited by 658
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles
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Metadata
- Authors
- Chinkers, M., McKanna, J. A., & Cohen, S.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1979-10-01
- Volume
- 83
- Issue
- 1
- Pages
- 260-265
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2007719101
- Cited by
- 295
- References
- 20
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chinkers, M., McKanna, J. A., & Cohen, S. (1979). Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors. The Journal of cell biology. https://doi.org/10.1083/jcb.83.1.260
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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