The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]
Open accessAbstract
Addition of EGF to human epidermoid carcinoma A431 cells increases the rate of fluid-phase pinocytosis 6-10-fold as measured by horseradish peroxidase uptake (Haigler, H.T., J. A. McKanna, and S. Cohen. 1979. J. Cell Biol. 83:82-90). We show here that in the absence of extracellular Na+ or in the presence of amiloride the stimulation of pinocytosis by EGF is substantially reduced. Amiloride had no effect on the endocytosis of EGF itself or of transferrin, demonstrating that the receptor-mediated endocytotic pathway operated normally under conditions that blocked stimulated pinocytosis. Amiloride blocked EGF-stimulated pinocytosis in both HCO3(-)-containing and HCO3(-)-free media. The EGF-stimulated pinocytotic activity can frequently be localized to areas of the cell where membrane spreading and ruffling are taking place. These results demonstrate that (a) EGF induces a distinct amiloride-sensitive endocytotic pathway on A431 cells; (b) occupied EGF receptors do not utilize this pathway for their own entry; (c) endocytosis of occupied EGF receptors is not in itself sufficient to stimulate pinocytosis.
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Cites
Fraker, P. J., & Speck, J. C. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91322-0 · Cited by 4,558
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W., & Schneider, W. J. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000245 · Cited by 1,600
Early Signals in the Mitogenic Response
Rozengurt, E. (1986) · Science · doi:10.1126/science.3018928 · Cited by 1,455
Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.
Boron, W. F., & De Weer, P. (1976) · The Journal of general physiology · doi:10.1085/jgp.67.1.91 · Cited by 919
Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins
Bar-Sagi, D., & Feramisco, J. R. (1986) · Science · doi:10.1126/science.3090687 · Cited by 734
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
Moolenaar, W. H., Tsien, R. Y., van der Saag, P. T., & de Laat, S. W. (1983) · Nature · doi:10.1038/304645a0 · Cited by 707
Hopkins, C. R., & Trowbridge, I. S. (1983) · The Journal of cell biology · doi:10.1083/jcb.97.2.508 · Cited by 637
Haigler, H., Ash, J. F., Singer, S. J., & Cohen, S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.7.3317 · Cited by 568
Wileman, T., Harding, C., & Stahl, P. (1985) · Biochemical Journal · doi:10.1042/bj2320001 · Cited by 565
Haigler, H. T., McKanna, J. A., & Cohen, S. (1979) · The Journal of cell biology · doi:10.1083/jcb.81.2.382 · Cited by 526
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Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
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Metadata
- Authors
- West, M. A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1989-12-01
- Volume
- 109
- Issue
- 6
- Pages
- 2731-2739
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1885102277
- Cited by
- 451
- References
- 40
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]. https://app.cochat.ai/papers/10.1083/jcb.109.6.2731
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- West, M. A. (1989). Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]. The Journal of Cell Biology. https://doi.org/10.1083/jcb.109.6.2731
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
