The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE
Open accessAbstract
A purified preparation of a polypeptide renin substrate prepared by tryptic degradation of the protein renin substrate has been analyzed by the fluorodinitrobenzene method and after degradation with renin, carboxypeptidase, and phenylisothiocyanate, has been found to possess the amino acid sequence; asp-arg-val-tyr-ileu-his-pro-phe-his-leu-leu-val-tyr-ser. The first 10 of these amino acids constitutes hypertensin I which is released by cleavage of the leucyl-leucine bond by renin. The remaining 4 amino acids, leu, val, tyr, ser, apparently link hypertensin I to the protein renin substrate.
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Citations
Cites
CHROMATOGRAPHY OF AMINO ACIDS ON SULFONATED POLYSTYRENE RESINS
Moore, S., & Stein, W. H. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77791-6 · Cited by 1,768
THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
Skeggs, L. T., Kahn, J. R., & Shumway, N. P. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.103.3.295 · Cited by 1,032
Self-citationRecent Developments in Techniques for Terminal and Sequence Studies in Peptides and Proteins
Fraenkel‐Conrat, H., Harris, J. I., & Levy, A. L. (1955) · Methods of Biochemical Analysis · doi:10.1002/9780470110188.ch12 · Cited by 629
THE EXISTENCE OF TWO FORMS OF HYPERTENSIN
Skeggs, L. T., Marsh, W. H., Kahn, J. R., & Shumway, N. P. (1954) · Journal of Experimental Medicine · doi:10.1084/jem.99.3.275 · Cited by 457
Self-citationTHE AMINO ACID SEQUENCE OF HYPERTENSIN II
Skeggs, L. T., Lentz, K. E., Kahn, J. R., Shumway, N. P., & Woods, K. R. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.104.2.193 · Cited by 204
Self-citationThe Plasma Proteins and Their Fractionation
Edsall, J. T. (1947) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60084-4 · Cited by 155
AMINO ACID COMPOSITION AND ELECTROPHORETIC PROPERTIES OF HYPERTENSIN I
Skeggs, L. T., Marsh, W. H., Kahn, J. R., & Shumway, N. P. (1955) · The Journal of Experimental Medicine · doi:10.1084/jem.102.4.435 · Cited by 55
Self-citationSkeggs, L. T., Kahn, J. R., & Shumway, N. P. (1951) · Circulation · doi:10.1161/01.cir.3.3.384 · Cited by 44
Self-citation
Cited by
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Renin-angiotensin system: biochemistry and mechanisms of action.
Peach, M. J. (1977) · Physiological Reviews · doi:10.1152/physrev.1977.57.2.313 · Cited by 1,378
The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition
Atlas, S. A. (2007) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2007.13.s8-b.9 · Cited by 722
Structure-based design of aliskiren, a novel orally effective renin inhibitor
Wood, J. M., Maibaum, J., Rahuel, J., Grütter, M. G., Cohen, N.-C., Rasetti, V., Rüger, H., Göschke, R., Stutz, S., Fuhrer, W., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01451-7 · Cited by 506
Drugs targeting the renin–angiotensin–aldosterone system
Zaman, M. A., Oparil, S., & Calhoun, D. A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd873 · Cited by 439
Metadata
- Authors
- Skeggs, L. T., Kahn, J. R., Lentz, K., & Shumway, N. P.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1957-09-01
- Volume
- 106
- Issue
- 3
- Pages
- 439-453
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2167192166
- Cited by
- 316
- References
- 8
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE. https://app.cochat.ai/papers/10.1084/jem.106.3.439
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- Skeggs, L. T., Kahn, J. R., Lentz, K., & Shumway, N. P. (1957). THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.106.3.439
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
