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DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS
Open accessAbstract
A marked reduction in numbers of cytoplasmic granules in rabbit and human polymorphonuclear leucocytes takes place following ingestion of various microorganisms or of a yeast cell wall preparation. The degranulation occurs within 30 minutes of phagocytosis, and is directly related to the quantity of material engulfed. White cells completely degranulated following phagocytosis of large numbers of microorganisms remain viable for at least 1 hour. The granules of polymorphonuclear leucocytes contain the antimicrobial agent, phagocytin, and various digestive enzymes. These substances thus are released into the cytoplasm or into vacuoles following ingestion of foreign material. The granule system and granule lysis mechanism may well play a central role in the primary function of these specialized cells; namely, that of destroying invading microorganisms.
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Citations
Cited by
Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282
Redox Reactions and Microbial Killing in the Neutrophil Phagosome
Winterbourn, C. C., & Kettle, A. J. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4827 · Cited by 468
Neutrophils in innate host defense against Staphylococcus aureus infections
Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400
Host defense and pathogenesis in Staphylococcus aureus infections
DeLeo, F. R., Diep, B. A., & Otto, M. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2008.10.003 · Cited by 269
“Concomitant with the production of ROS, neutrophil cytoplasmic granules fuse with bacteria-containing phagosomes, a process called degranulation.(45) Fusion of azuro-”
BackgroundMartínez, A., Prolo, C., Estrada, D., Rios, N., Alvarez, M. N., Piñeyro, M. D., Robello, C., Radi, R., & Piacenza, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821487116 · Cited by 41
Metadata
- Authors
- Hirsch, J. G., & Cohn, Z. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1960-12-01
- Volume
- 112
- Issue
- 6
- Pages
- 1005-1014
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129441674
- Cited by
- 332
- References
- 0
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS. https://app.cochat.ai/papers/10.1084/jem.112.6.1005
- The paper
- Hirsch, J. G., & Cohn, Z. A. (1960). DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.112.6.1005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
